Wellcome Trust Sanger Institute

Computational Postdoctoral Fellow - Cancer Drug Combinations

Wellcome Trust Sanger Institute

Cambridge, United Kingdom

Computational Postdoctoral Fellow – Cancer Drug Combinations
Salary range £31,897 – £39,240 (dependent on experience) plus excellent benefits
Fixed Term for 3 Years

The Garnett lab is seeking a computational postdoctoral scientist to use CRISPR-Cas9 screening to identify combination targets for cancer.

Many cancer patients have tumours with resistance to standard of care therapy or have amolecular context that is not addressed by current treatments. Combination therapies aimed at inhibiting multiple targets or cancer pathways can combat resistance and exploit new actionable dependencies in defined genetic contexts. The aim of this study is to exploit the power of large-scale CRISPR screening in cancer cell lines to identify and investigate new target combination for cancer.

A postdoctoral position is available in the Garnett lab as part of a collaborative research team. The position involves development of analytical and statistical approaches to model gene-gene interactions using large-scale CRISPR screening datasets, and combining these results with genomic data, transcriptomic and proteomic datasets.

This project forms part of the Open Targets collaboration, a private-public partnership between academia and industry, including the Sanger Institute, the European Bioinformatics Institute (EBI: Petsalaki lab), European Molecular Biology Laboratory (EMBL: Zaugg lab) and pharmaceutical companies as part of the Open Targets community.

You should have a PhD in computer science, cancer bioinformatics or related discipline, with experience working with large-scale genomic and functional genomic datasets.

You will be team players, have excellent organizational skills, and strong verbal and written communications skills, as well as a proven track record of productivity. Postdoctoral fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3-year fixed term.
Further details of the Garnett lab (https://www.sanger.ac.uk/science/groups/garnett-group) and Open Targets (https://www.opentargets.org/) are available at the provided links.

Essential Skills
• PhD in cancer biology, cancer therapeutics, molecular biology, or related discipline
• Excellent communication, organisational and presentation skills
• Excellent problem solving and troubleshooting skills
• Ability to work independently and organize own workload
• Ability to organize, plan and prioritize tasks or projects
• Demonstrates good networking, influencing and relationship building skill
• Ability to communicate ideas and results effectively
• Evidence of good productivity through publications, presentations, patents or otherwise.

Ideal Skills
• Experience using CRISPR-based screening approaches
• Experience performing high-throughput screens

Other information
Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
• Defined Contribution Pension Scheme and Life Assurance
• Group Income Protection
• Private Health Insurance
• 25 days annual leave, increasing by one day a year to a maximum of 30
• Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
• Two days paid Employee Volunteering Leave a year
• Employee Discount Scheme
• Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
• Active Campus Sports and Social Club
• Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application.
Closing date: 9th June 2019

Please apply via recruiter’s website.