Faculty Member: Lewis Zhichang Shi, MD, PhD, Associate Professor, Departments of Radiation Oncology and Microbiology, Program in Immunology, O’Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233
Job Description: Postdoctoral Scholarships are available to study the underlying mechanisms for cancer immunotherapy, particularly immune checkpoint blockade (ICBs such as anti-CTLA-4 and anti-PD-1/-L1). We are also interested in identifying new targets for cancer interventions that can be combined with ICB and adoptive T cell therapy. Our recent work revealed tumor cell-intrinsic (Cell 167: 397 (2016)) and –extrinsic (Nat Med 23: 551 (2017)) resistant mechanisms, as well as T cell-intrinsic pathways underlying ICBs (Nat Commun 7: 1 (2016); CIR 7: 1803 (2019)). Another line of research in the lab is to understand how T cell development, activation, and functional differentiation are transcriptionally and metabolically controlled (Mol Immunol (2019), PNAS (2013 and 2017), J Exp Med (2011), and Immunity (2011)). The experimental models include genetically-modified mice and disease models for cancer, autoimmunity, infections, and inflammation.
Job Qualifications: Highly motivated individuals with a recent Ph.D. in immunology, cancer biology, or molecular biology are encouraged to apply.
Application Instructions: Please send a CV, including contact information for three references, to email@example.com. UAB is currently ranked as the #1 Young U.S. University by Times Higher Education, and #1 U.S. University for Postdoctoral Fellows by The Scientist. It is ranked #20 of all U.S. institutions in annual NIH funding.
UAB Comprehensive Cancer Center is one of the nation’s leading cancer research and treatment centers. It is one of the original eight cancer centers in the country that earned the prestigious National Cancer Institute “comprehensive” cancer center designation in 1971. UAB’s cancer services are routinely recognized as being among the nation’s best.
UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of race, national origin, age, genetic or family medical history, gender, faith, gender identity and expression as well as sexual orientation.