Brown Lab Research Fellow
Dana-Farber Cancer Institute
Chronic lymphocytic leukemia (CLL) remains the most common leukemia of adults and is incurable. Several novel therapies have substantially altered the treatment landscape for CLL, and studying mechanisms of resistance to these therapies is of great interest. Our lab focuses on CLL and the genomics of CLL with several particular interests, one of which is identifying mechanisms of resistance to novel therapies, especially kinase inhibitors. We are currently applying genomic techniques including whole exome and genome sequencing to this problem. Check out our lab here: https://brownlab.dana-farber.org
This fellowship will focus on the analysis of sequential baseline, remission and resistance samples from patients treated with novel targeted agents in CLL, including PI3K inhibitors in particular but also other agents (BTK inhibitors and venetoclax), with a focus on exome and RNA sequencing data. The ideal candidate will be able to perform their own bioinformatics analyses of these data and will support others in the lab in their analyses of similar data. Validation of key findings at the bench will also be required. The ideal candidate will have familiarity and experience working with molecular genetics/genomics and bioinformatics, as well as cloning, validation, and studies of the biologic function of candidate mutations.
• Previous experience in molecular biology and informatics is required. This position will focus especially on high-throughput genomic analyses and requires good computational skills and familiarity with bioinformatics.
• MD, PhD or MD/PhD is required.
For more information, or to apply, please visit: https://careers-dfci.icims.com/jobs/18697/brown-lab-research-fellow/job
About Dana Farber:
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.