St. Jude Children's Research Hospital (St. Jude)

Biotech Scientist (Blood cell development and disorders)

St. Jude Children's Research Hospital (St. Jude)

Memphis, TN, United States


At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.

In anticipation of future growth,  we are seeking outstanding, highly motivated, and creative candidates for scientist roles in a new clinical genome editing group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.

You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.

You will have the opportunity to learn about and support new exciting projects such as:

  • Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin.
  • Process development and IND-enabling studies (Pharm/Tox)

Apply today! A cover letter is highly recommended.


  • Perform studies to improve genome editing and culture of human hematopoietic stem cells. 
  • Design and execute IND-enabling experiments to characterize the pharmacology of a genome edited human hematopoietic stem cell product to treat sickle cell disease. 
  • Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays. 
  • Interact and collaborate with multidisciplinary team to advance the program. 
  • Evaluate scale-up and close-system processes to ensure reproducibility of drug product. 
  • Establish tracking and trending analyses of process development and pilot runs. 
  • Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. 

Minimum Education

  • PhD in Life Sciences, Bioengineering, or related discipline.

Minimum Experience

  • Strong experience and knowledge in hematology and hematopoietic stem cell biology.
  • Experience in cell-based therapy culture and process. 
  • Experience with genome editing tools (Nucleases/base editing) 
  • Ability to communicate effectively with strong communications skills and a collegial personality. 
  • Ability to operate in a fast-paced, multi-disciplinary environment. 
  • Must be an independent thinker, meticulous, detail-oriented, and analytical. 
  • Must be highly motivated, have excellent organizational, communication and interpersonal skills. 
  • Must be able to work independently and as part of a multi-disciplinary team. 

Preferred Qualification

  • cGMP experience in the cell and gene therapy spaces.
  • Experience within biotech/pharmaceutical company or a CRO/CMO.
  • Experience in biologics manufacturing.
  • Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines.
  • Experience in NGS sequencing and data analysis.
  • Experience in automated cell processing systems such as Sepax, CliniMACS Prodigy & Plus, bioreactors, or other cell therapy processing instruments.
  • Familiarity with flow cytometry; analysis and sorting.
  • Animal experience, familiar with humanized mouse xenotransplantation models (NSG/NBSGW

EEO Statement

St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Apply for this position now.

Please apply via recruiter’s website.