GlaxoSmithKline plc. (GSK)

Biophysical Senior Scientist

GlaxoSmithKline plc. (GSK)

Stevenage, East of England, United Kingdom

GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Molecular Discovery (BPMD) is a department within GSK’s Drug Design and Selection group dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling. Within the BPMD Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling to continuously improve molecule quality and transform discovered leads into potential therapeutics prior to candidate selection.

We are currently seeking a keen, dynamic and self-motivated Senior Scientist to join the developability profiling group within MDE. The role will be lab-centric and will involve profiling/characterizing a panel of biopharmaceuticals based on their biophysical and physicochemical properties, performing interpretations on the generated data and conveying the outcomes to early program teams. Experience in liquid handling systems and data automation would be beneficial. 

The successful candidate will have experience in one or more biophysical techniques such as dynamic/static light scattering, differential scanning calorimetry, analytical size exclusion chromatography etc., and ideally experienced in using these to characterize the structure and/or stability of proteins. Although predominantly lab-based, the role also requires effective communication (both oral and written), organizational, interpersonal and teamwork skills.

Please take a copy of the Job Description, as this will not be available post closure of the advert. 

Close date; 8th December 2019

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Required Attributes

  • PhD or equivalent academic/industry experience in biophysics or related discipline

    • 2-3 years relevant lab based work experience
  • Experienced scientist with proficiency in one or more of the following analytical/biophysical methods: dynamic/static light scattering, differential scanning calorimetry, analytical size exclusion chromatography, mass spectrophotometry, fluorescence/UV spectroscopy, capillary iso-electric focusing etc.
  • Good understanding of antibody sequence/structure-function relationship
  • Good analytical and data interpretation skills
  • Strong written and verbal communication skills
  • Strong attention to detail in experimental setup; capability to multitask and run multiple experiments in parallel, good organisational and prioritisation skills
  • Strong computing skills for data handling, reporting (written & oral) and experimental lab book write-ups
  • Quick adaptability in new scientific areas, working across teams and the use of lab instrumentation
  • Ability to review and assimilate information effectively

Preferred Attributes

  • Experience of applying biophysical and biochemical analytical methods to a range of protein molecular formats
  • Experience in analytical and liquid handling automation systems
  • Experience of automated data analysis and/or visualization software e.g. Spotfire, JMP
  • Knowledge and/or practical lab experience in some or all the areas listed below:
  • Protein purification
  • Chemical Manufacturing Control (CMC)

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

We’re open to all talent – whatever your gender, disability, marital status, religion or belief, age, race, sexual orientation, ethnic or national origin.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don’t hesitate to contact us if you’d like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email

As you apply, we will ask you to share some personal information which is voluntary. This will be used to help us understand how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information, it is not used in any part of the selection process and we will treat your information confidentially and use it anonymously.

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