GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
Biopharm Molecular Discovery (BPMD) is a department within GSK’s Drug Design and Selection group dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling. Within the BPMD Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling to continuously improve molecule quality and transform discovered leads into potential therapeutics prior to candidate selection.
We are currently seeking a keen, dynamic and self-motivated Senior Scientist to join the developability profiling group within MDE. The role will be lab-centric and will involve profiling/characterizing a panel of biopharmaceuticals based on their biophysical and physicochemical properties, performing interpretations on the generated data and conveying the outcomes to early program teams. Experience in liquid handling systems and data automation would be beneficial.
The successful candidate will have experience in one or more biophysical techniques such as dynamic/static light scattering, differential scanning calorimetry, analytical size exclusion chromatography etc., and ideally experienced in using these to characterize the structure and/or stability of proteins. Although predominantly lab-based, the role also requires effective communication (both oral and written), organizational, interpersonal and teamwork skills.
Please take a copy of the Job Description, as this will not be available post closure of the advert.
Close date; 8th December 2019
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
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- PhD or equivalent academic/industry experience in biophysics or related discipline
- 2-3 years relevant lab based work experience
- Experienced scientist with proficiency in one or more of the following analytical/biophysical methods: dynamic/static light scattering, differential scanning calorimetry, analytical size exclusion chromatography, mass spectrophotometry, fluorescence/UV spectroscopy, capillary iso-electric focusing etc.
- Good understanding of antibody sequence/structure-function relationship
- Good analytical and data interpretation skills
- Strong written and verbal communication skills
- Strong attention to detail in experimental setup; capability to multitask and run multiple experiments in parallel, good organisational and prioritisation skills
- Strong computing skills for data handling, reporting (written & oral) and experimental lab book write-ups
- Quick adaptability in new scientific areas, working across teams and the use of lab instrumentation
- Ability to review and assimilate information effectively
- Experience of applying biophysical and biochemical analytical methods to a range of protein molecular formats
- Experience in analytical and liquid handling automation systems
- Experience of automated data analysis and/or visualization software e.g. Spotfire, JMP
- Knowledge and/or practical lab experience in some or all the areas listed below:
- Protein purification
- Chemical Manufacturing Control (CMC)
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