GlaxoSmithKline plc. (GSK)

Biophysical Scientist – Antibody Developability

GlaxoSmithKline plc. (GSK)

Stevenage, United Kingdom

We are currently seeking a keen, dynamic and self-motivated lab scientist to join the developability profiling group within Molecular Design and Engineering (MDE). The role will be lab-centric and will involve profiling/characterising a panel of biopharmaceuticals based on their biophysical and physiochemical properties, performing interpretations on the generated data and conveying the outcomes to early programme teams.

Within the Biopharm Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.

Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling.

The successful candidate will have extensive experience in one or more biophysical techniques such as dynamic light scattering, analytical ultracentrifugation, differential scanning calorimetry, analytical size exclusion chromatography and ideally be experienced in using these to characterise the structure and/or stability of proteins. Although predominantly lab based, the role also requires effective communication skills (both oral and written), organisational, interpersonal and teamworking skills.

GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Closing date for applications: Sunday 8th March

Please take a copy of the Job Description, as this will not be available post closure of the advert. 

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Basic Qualifications:

  • MSc/PhD or equivalent in protein analytics, biochemistry, biophysics or a related discipline
  • Experienced scientist with proficiency in protein analytics using one or more of the following methods: mass spectrometry, analytical ultracentrifugation, dynamic/static light scattering, SEC-HPLC, RP-HPLC, fluorescence/UV spectroscopy, capillary isoelectric focussing, etc
  • Good analytical and data interpretation skills
  • Attention to detail in experimental setup; capability to multitask and run multiple experiments in parallel, good organisational and prioritisation skills
  • Quick adaptability in new scientific areas, working across team and the use of lab instrumentation

Preferred Qualifications:

  • Experience of working with therapeutic antibodies
  • Experience of developing miniaturized/high throughput assays
  • Knowledge and/or practical lab experience in Protein purification/CMC
  • Knowledge of antibody sequence/structure-function relationship
  • Understanding of Antibody Discovery processes

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

We’re open to all talent – whatever your gender, disability, marital status, religion or belief, age, race, sexual orientation, ethnic or national origin.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don’t hesitate to contact us if you’d like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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Please apply via recruiter’s website.

Quote Reference: 233544