St. Jude Children's Research Hospital (St. Jude)

Bioinformatics Research Scientist Drug Targets

St. Jude Children's Research Hospital (St. Jude)

Memphis, TN, United States


The joint laboratory of Drs. Anang Shelat and Christopher Tinkle are looking for an innovative and highly motivated Bioinformatics Research Scientist to help identify and clinically translate targeted drug combination strategies for diverse pediatric cancers.  Two areas of interest in the lab are: (a) the application of genome instability assessment coupled with machine learning to identify and predict functional deficits in DNA repair to guide treatment or identify novel drug targets; and (b) the identification of rational combination strategies using small molecule epigenetic modifiers to target tumor-specific transcriptional states. The applicant will have the opportunity to participate in interdisciplinary disease-oriented projects teams alongside clinicians, chemists, biostatisticians and pharmacologists, with the ultimate goal of translating research findings into clinical trials for children with cancer.

Applicants should have extensive experience in the use of established bioinformatics pipelines to process transcriptomic, genomic, and epigenomic data, and the ability to rapidly learn and deploy new methods. Experience with omics data analysis using R, Python, or other languages in HPC environment is required. Expertise in systems biology and cancer biology, specifically related to the DNA damage response and repair and/or chromatin modulation in response to cellular stress, is preferred.  Expertise in data visualization and machine learning is also highly desirable. The applicant will have the opportunity to work closely with members of the Center for Applied Bioinformatics in order to apply state-of-the-art analytical tools and platforms to mine genomics data.

St. Jude offers an exceptional research environment, including state-of-the-art high-performance computing facilities, robust analytical pipelines, access to unique pediatric cancer data sets, and outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science.

Minimum Education

  • Bachelor’s degree is required.
  • Master’s degree or PHD is preferred.

Minimum Experience

Bioinformatics Research Scientist

  • Seven (7) years of relevant post-degree work experience is required.
  • Five (5) years of relevant post-degree work experience is required with a Master’s degree.
  • Two (2) years of relevant post-degree work experience is required with a PhD.

Lead Bioinformatics Analyst

  • Six (6) years of relevant experience is required.
  • Four (4) years of relevant experience may be acceptable with a Master’s degree.
  • No experience may be acceptable with a PHD in Computer Science or Bioinformatics, with a background in the biological sciences.
  • Experience in programming (Python, Java, C/C++, perl or other programming/scripting languages) under linux/unix environment is required.
  • Experience with and the ability to deal with a wide range of users is required.
  • Experience of independent data analyses and project management is required.

EEO Statement

St. Jude is an Equal Opportunity Employer


No Search Firms:

St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Please apply via recruiter’s website.