IBG-1 – Biotechnologie
Area of research:
Diploma & Master Thesis
Contract time limit:
Background: The focus of the `Synthetic enzyme cascades´ (aka Biokat) group is to develop multienzymatic cascades towards high-value products (eg. pharmaceuticals), which cannot be easily obtained from nature or from chemical synthesis, usually starting from bio-based and cheap substrates.
The HOTZYMES project: This cutting-edge project envisions the on-demand activation and regulation of enzymatic activity in one-pot multi-enzymatic cascade system by applying an alternating magnetic field (AMF) to it. The main challenges for this project are: (i) coordinating the optimal reaction conditions for one-pot multi-enzymatic system, (ii) matching the optimal temperature for each enzyme, and (iii) avoid cross-reactivity of enzymes and the formation of by-products. The overall aim of HOTZYMES is to tackle these challenges simultaneously by gaining selective spatial-temporal control over each enzyme activity by means of local heating due to molecular movement induced by a magnetic field. This is a FET-OPEN project funded by the Horizon 2020 EU program and is part of an interdisciplinary consortium involving seven partners across Europe.
More information can be found in our website: www.hotzymes.eu/about/
Your qualifications: We are looking for a highly motivated student of biochemistry, applied chemistry, biotechnology, or a related field with (very) good grades and strong interest in interdisciplinary research. Prior hands-on experience with microbiology, biocatalysts and instrumental analytics (photometric assays, HPLC, and NMR) would be very advantageous. Good English skills are also expected.
EXPECTED START DATE: March 2020