Wellcome Trust Sanger Institute

Advanced Research Assistant

Wellcome Sanger Institute

Cambridge, United Kingdom

Advanced Research Assistant
Salary range £26,960 – £32,622 depending on experience plus excellent benefits
Fixed Term contract for 1 or 2 years.

We are seeking to appoint a highly motivated individual to provide laboratory research support for the Soranzo team (http://www.sanger.ac.uk/research/faculty/nsoranzo/) at the Wellcome Sanger Institute.

The group’s primary research interest is to investigate the effect of genetic variation on human phenotype, including quantitative organismal and molecular traits, combining statistical analyses and functional genomics approaches. We have recently revealed thousands of loci at high resolution for common and rare genetic variants which affect human blood cell traits (Astle et al Cell 2016). Through integration with large scale molecular phenotyping, including characterising layers of transcription and epigenetic states, we have begun to resolve the molecular mechanisms in which these variants act.

We are now looking to recruit an Advanced Research Assistant to work on new and exciting projects further elucidating these observations. The primary goal of this work will be to apply large scale genetic screens to test the functional consequences of common and rare genetic variants implicated in haematopoietic cell development and function.

Your primary responsibility will be to contribute to the team’s research by supporting laboratory projects involving cell culture and genetic engineering techniques. This project offers the opportunity to work in a multi-disciplinary team building upon recently published and diverse data sets with the potential to apply various molecular biology and genome editing technology to answer key questions affecting human biology. You will work in close collaboration with computational scientists and have significant opportunities to work in collaboration with other groups at the Institute.

The post will be for one year initially with possible opportunity to extend to two years.

Essential Skills

• Degree in Biological Sciences, Molecular Biology or equivalent significant experience in a relevant area
• Previous work experience as a technician/research support in a molecular biology laboratory
• Experience in mammalian cell culture including primary cells and ideally also induced pluripotent stem cells
• Extensive experience of core molecular biology techniques, including cloning procedures (plasmid purification, digestion and transformation), sample prep, RT & qPCR, RNA/DNA extraction
• Excellent organizational, communication skills and work ethic
• Ability to develop, optimize and deploy research support, as a member of a closely collaborative team

Ideal Skills

• Experience of high-throughput genomic screens
• Application of genome editing through CRISPR-Cas9 or similar techniques
• Experience in single-cell technologies
• Experience in transformation techniques such as lentiviral transformation

Other information
The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
• Defined Contribution Pension Scheme and Life Assurance
• Group Income Protection
• Private Health Insurance
• 25 days annual leave, increasing by one day a year to a maximum of 30
• Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
• Two days paid Employee Volunteering Leave a year
• Employee Discount Scheme
• Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
• Active Campus Sports and Social Club
• Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date: 15th June 2019

Please apply via recruiter’s website.