Center for Single-Cell Omics
The Shanghai Jiao Tong University School of Medicine Center for Single-Cell Omics (CSCOmics) is a new initiative with its own, completely renovated research building on our medical campus in downtown Shanghai. The CSCOmics hosts state-of-the-art single cell equipment and opened its door on November 3, 2019, with a symposium “Single-cell omics in aging and disease” (https://www.shsmu.edu.cn/sph-cscomics). We already recruited several Principal Investigators and now also invite qualified candidates to apply for the following positions:
Administrator. He/she will be responsible for the day-to-day operations of the CSCOmics. This includes assistance to the Principal Investigators with grant applications, preparing budgets, including the annual budget of the CSCOmics as part of the School of Public Health, organizing meetings and travel, timely reimbursements, purchasing equipment and supplies, as well as taking care of various aspects related to office and laboratory maintenance. To perform these tasks the Administrator of the CSCOmics will have an administrative assistant, who is already in place. The Administrator will report to the Director. The successful candidate will have excellent interpersonal skills and the ability to communicate effectively, both verbally and in writing, in Chinese and English. The ability to work cooperatively with PIs, Core Directors, and students is essential, as is the desire and ability to work well in a team environment. Minimum qualifications include a master’s degree in business administration, biology or medical background is an advantage.
Core Directors. We seek Core Directors for our “Single-cell identification and isolation”, “Single-cell DNA sequencing” and “Single-Cell Biostatistics & Bioinformatics” cores, who will be appointed as assistant professors.
For the “Single-cell identification and isolation core” tasks are to provide services to the CSCOmics PIs, PIs at our medical campus in general as well as PIs from outside our own school. Services include the isolation of single cells from blood, cell or tissue samples, including human clinical samples using a variety of approaches, including single cell handling (CellRaft, Fluxion Isoflux, ALS CellCelector, CellenOne X1, MD Single Cell Printer), FACS (MoFlo Astrios), and LCM (MMI CellCut). Minimum qualifications include a Ph.D. degree in biological sciences and a minimum of five (5) years of relevant postdoctoral experience with cell and tissue culture, FACS sorting, cellular imaging and advanced microscopy, as well as basic molecular biology techniques. Since all downstream analyses include genomics, transcriptomics, proteomics or metabolomics, preference will be given to those with some experience with these techniques.
For the “Single-cell DNA sequencing core” tasks are to provide single-cell, next-generation sequencing services to the CSCOmics investigators and PIs on campus in general with a short turnaround time, using the latest Illumina sequencers (NextSeq550, NovaSeq6000). Services offered include 10X Chromium Single Cell Gene Expression sequencing, single-cell RNA-seq, Single Cell Immune Profiling (VDJ), Single Cell Transposase Accessible Chromatin (ATAC) sequencing, and other applications.
For the “Single-Cell Biostatistics & Bioinformatics Core” the Director will provide Core services to CSCOmics investigators and investigators outside the CSCOmics in the analysis of raw data generated through single-cell analysis of DNA, RNA, proteins and metabolites. This includes the processing, analysis, integration, and visualization of data, as well as functional annotations. The Director of this core will establish pipelines, ensures workflow automation, and pathway and network analysis, including data visualization.
All our core leaders have the opportunity to do research of their own as long as this serves the interest of the end users. For example, optimization, improving existing technology and developing new, advanced applications is strongly encouraged. Publication, either as co-author or as senior author is important. The two core leaders presently sought will closely collaborate with our “Single-cell genomics core” , “Single-cell bioinformatics” and “Single-cell mass spec” Core Directors.
The successful candidates will have excellent interpersonal skills and a service-oriented mindset. Good communication skills are critically important and the candidates should be able to speak and write both Chinese and English fluently. Minimum qualifications are at least 3 years postdoc experience and a publication track record of expertise.
PostDocs. We are looking for several postdocs to independently perform research projects in order to jointly realize the objectives of our research program “Developing novel targeted therapies and CAR-T cell immunotherapies for patients with pancreatic cancer” (Group Professor Christopher Heeschen). We have developed an array of innovative methods that allow in vitro and in vivo functional interrogation of rare cancer stem cells. We aim to identify common regulators of cancer stem cell functions that are amenable to therapeutic intervention and eventually translation into the clinic. The successful candidate will be focusing on newly identified targets specifically expressed by these rare cancer stem cells. The project will span a broad spectrum of advanced in vitro and in vivo techniques, including single cell handling and analysis. All techniques have been developed/established in the lab. Minimum qualifications include a PhD degree in life science and relevant experience will provide an advantage. Excellent communication skills in English are mandatory.
Technicians. We are looking for multiple technicians to perform a variety of tasks assisting Principal Investigators with their research and Core Directors with the services they provide. Tasks include cell isolation and culture, cell manipulation and imaging, genome, transcriptome, proteome and metabolome analysis, work with mice, as well as facility and equipment maintenance. Minimum qualifications include a Master’s degree or equivalent and relevant experience will provide an advantage.
Successful candidates will have excellent interpersonal skills and the ability to communicate effectively both verbally and in writing. The ability to work cooperatively with supervisors, faculty and students is essential, as is the desire and ability to work well in a team environment. Careful observation and objective assessment skills are required, as is the ability to keep accurate records and prepare reports. Basic knowledge of cell biology and tissue culture is imperative. Experience with in vivo models is desirable. Candidates are expected to provide intellectual commitment by keeping up with appropriate literature and research publications. They can be asked to develop, modify and improve standard operating procedures, and use computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
Since these positions will assist scientists with an international background in performing scientific research of high complexity, they will need to communicate effectively in both Chinese and English and be able to calculate and record results at high accuracy. They should maintain a detailed notebook in English of all work-related activities.
For all positions, we strive to attract qualified candidates from across the globe with a strong focus on diversity and the equal representation of women and men. Salaries and benefits are highly competitive. With English serving as the common communication channel, proficiency in Chinese is not required. However, we do provide a free course in Mandarin Chinese as well as Chinese culture.
Shanghai Jiao Tong University School of Medicine offers a rich and collaborative intellectual environment with state-of-the-art support facilities. Shanghai is a highly cosmopolitan city and one of China’s main technology hubs at all levels.
CVs and supplements should be sent to the following 3 email addresses:
Dr. Jan Vijg: email@example.com
Dr. Hui Wang: firstname.lastname@example.org
Public address: email@example.com