- University of Michigan (U-M)
- Ann Arbor
- 08 Feb 2023
- 09 Apr 2023
- Job Type
- Employment - Hours
- Full time
- Fixed term
Postdoctoral positions are available in the Abdel-Latif lab in the Department of Medicine, Division of Cardiology at The University of Michigan, AnnArbor. Our laboratory focuses on utilizing systems approaches to identify key therapeutic opportunities in cardiac remodeling specially in the setting of stress and injury.
We are seeking highly motivated candidates with experience in cardiac research, cardiac ischemic injury, cardiac imaging and RNAseq analysis and interpretation to work on funded grants focused on modulating the imminent system to enhance cardiac recovery after ischemic injury. The candidates will also have opportunities to develop highly impactful projects based on their research interests.
Successful experimentally focused postdocs will have experience with standard molecular biology techniques and in vivo mouse experiments. Successful computationally focused postdocs will be able to integrate diverse “-omics” datasets and patient clinical information, including experience with standard languages (e.g., Python, R). The successful candidate will utilize molecular, genetic and pharmacological approaches and relevant in vivo disease models to decipher the molecular mechanisms involved. Prior experience in molecular biology, flow cytometry, mouse genetics, animal handling and cardiac imaging and surgical techniques is highly desirable. A strong background in immunology and myocardial inflammation is preferable. Candidates with a Ph.D. in cell/ molecular biology, immunology, physiology/pharmacology or a related discipline are encouraged to apply.
The University of Michigan, Ann Arbor is ranked by U.S. News & World Report as the top hospital for cardiac care in the nation. The University of Michigan-Franknel Cardiovascular Research Center has a group of outstanding scientists in cardiovascular research, especially in cardiovascular cell signaling, obesity, diabetes, endothelial and platelet biology, and pathogenesis of atherosclerosis. Successful applicants will have the opportunity to work with them and get help in developing an independent career in this research field.
All applicants should have strong communication skills and experience preparing scientific manuscripts. Interested applicants should send a cover letter describing your previous experience and future research plans along with a detailed CV and at least three references to:
Ahmed Abdel-Latif, MD, PhD
Interested applicants can apply through the University of Michigan website: Research Fellow posting #230007on the https://careers.umich.edu/ page.
The University of Michigan, Ann Arbor is an Equal Opportunity Employer –M/F/Veteran/Disability –committed to the hiring, advancement and fair treatment of all individuals.
Please do consult recent publications from the Abdel-Latif lab for more information on our scientific projects:
Tripathi H, Shindo K, Donahue RR, Gao E, Kuppa A, ElKammar M, Morris AJ, Smyth SS, Abdel-Latif A. Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3) Increases Cardiac Inflammation After Myocardial Infarction. Arterioscler Thromb Vasc Biol 2022 (Online ahead of print). PMID: 36453277
eng H, Shindo K, Donahue RR, Gao E, Ahern BM, Levitan BM, Tripathi H, Powell D, Noor A, Elmore GA, Satin J, Seifert AW, Abdel-Latif A. Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction. Nat Regen Med 2021: 6 (1):74. PMID: 34789749.
Peng H, Chelvarajan L, Gottipati A, Abdel-Latif A, Berron B. Polymer cell surface coating enhances mesenchymal stem cell retention and cardiac protection. ACS Appl Bio Mater 2021; 4 (2):1655-1667. PMID: 35014513.
Tripathi H, Al-Darraji A, Chelvarajan L, Levitan B, Ye S, Morris AJ, Smyth SS and Abdel-Latif A. Autotaxin inhibition reduces inflammation in a myocardial infarction pre-clinical model: potential therapeutic targets in ischemic heart disease. J Mol Cell Cardiol, 2020: S0022-2828(20)30291-1. PMID: 33017574.
Abdel-Latif A, Ahmed T, Leung SW, Alnabelsi T, Tarhuni W, and Sekela ME. Autologous CD133+ Cells and Laser Revascularization in patients with severe Ischemic Cardiomyopathy. Stem Cell Rev Rep. 2022 (Online ahead of print). PMID: 36376770
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