Postdoc (f/m/d)

^{letzte Änderung: 19.01.2023}

The laboratory of Prof. Dr. Mathias Heikenwälder in the newly built, interdisciplinary research institute M3 in Tübingen and DKFZ-University of Heidelberg is looking for a

Postdoc (f/m/d)

The fulltime position is available for two years, with the possibility of prolongation. Expected staring date is 1st May 2023, but can also be negotiated.

The Research department “Chronic inflammation and Cancer” led by the Director of the M3 (Malig-nome, Metabolome, Microbiome) Research Institute Prof. Dr. Mathias Heikenwälder – studies the molecular mechanism by which chronic inflammation can lead to the development of cancer. A major focus of the research is devoted to the question, how high energy diets or alcohol cause the develop-ment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and subse-quently liver cancer (HCC and CCC) and how the immune system modulates theses pathologies. We finally aim to generate models of chronic inflammation potentially used for pre-clinical research and also engage in clinical trials with patients at the UKT. Thus, we focus on comparative studies of human and animal model tissues, recapitulating human disease on a functional, histo-pathological and pathophysiological level. We are a world leader in the field of liver cancer, NASH, chronic inflammation, metastasis and immunotherapy (selected publications: Pfister et al., Nature 2021; Dudek et al., Nature 2021; Conlon et al., Nature 2020; Malehmir et al., Nature Medicine 2019; O´Connor et al., Cancer Cell 2019; Yuan et al., Cancer Cell 2017; Boege et al., Cancer Cell 2017; Lucifora et al., Science 2014; Wolf et al., Cancer Cell 2014; Wolf et al., Cancer Cell 2012; Haybaeck et al., Cancer Cell 2009).

To complement and extend our team at the newly build M3 Research Institute as well as at the DKFZ (German Cancer Research Center), we are looking for a Postdoc candidate, with high interest and knowledge in the fields of chronic inflammation and cancer.

Your work will focus on deciphering novel molecular and cellular mechanisms that control inflammation induced liver cancer and how the latter would affect therapy response - using preclinical mouse models as well as patient material/ patient cohorts.

Your tasks will include:

• Independent project and experimental planning
• Supervision and training of a PhD student
• To perform practical experimental work by applying various molecular, cell-biological and histological methods as well as animal experiments (mouse)
• Work with human tissue specimen and bodily fluids
• Oral and written presentation of the gained results (presentations, talks, reports, publication in international scientific journals)
• Taking over responsibilities for team duties

We provide:

• A motivated international team
• An environment that integrates your personal aim and the aims of the laboratory
• Career development and mentorship
• A vivid, vibrant and joyful research environment at the highest level
• Possibility to pursue your research interest in the frame of chronic inflammation and can-cer using multiple approaches at highest level

Necessary qualifications: PhD in natural science or MD with several years research experience, Felasa B Certificate or equivalent.

Desired qualifications: Independent functioning, capacity for teamwork, intercultural competence, practical experience in standard molecular and cell biological methods, publication in an international peer reviewed scientific journal.

For informal enquiries, please contact Prof. Dr. Mathias Heikenwälder (m.heikenwaelder@dkfz-heidelberg.de).
Division of Chronic Inflammation and Cancer - https://www.dkfz.de/en/chronische-entzuendung-und-krebs/team/heikenwaelder.html

We apply the collective agreement for the public service of the federal states (TV-L), severely disabled persons are given priority in case of equal suitability. Presentation costs can unfortunately not be covered. Please observe the applicable vaccination regulations. As the University of Tübingen aims to increase the proportion of women among its academic staff, women are strongly encouraged to apply. Employment is based on the relevant provisions of university law.

We would be delighted to receive your application including a letter of motivation, CV, relevant tran-scripts, list of publications, and two references. Please send your full application as a single PDF file to Prof. Dr. Mathias Heikenwälder (m.heikenwaelder@dkfz-heidelberg.de).

Universitätsklinikum Tübingen
Medizinische Klinik
Herr Mathias Heikenwälder
Otfried-Müller-Straße 37
72076 Tübingen

E-Mail: m.heikenwaelder@dkfz-heidelberg.de