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2 funded postdoc positions: ERC project - de novo protein design, high-throughput biophysics

Employer
VIB
Location
Brussels
Closing date
13 Oct 2024

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Discipline
Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
Professional certification
Sector
Academia
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Job Details

Overview Two postdoc positions are available at the Laboratory of Computational Protein Design in Brussels (https://vorobievalab.sites.vib.be/en) and are funded by an ERC grant. The focus of the group is the de novo design of membrane proteins and nanopores for applications such as single-molecule sensing. In that context, this ERC project aims to (i) develop a new experimental platform for high-throughput characterization of the biophysical properties of natural and synthetic protein nanopores and (ii) leverage the generated data for the development of better computational design methods based on the Rosetta software and the latest generative deep learning software for protein design.

We are therefore looking for two profiles with interest in the design of membrane proteins:

Profile 1

Recent Ph.D. in experimental protein engineering/directed evolution.

Demonstrated experience in:

  • Developing and using high-throughput assays.
  • Library construction (mutagenesis, oligo pools).
  • Recombinant expression, purification and characterization of proteins.
  • Deep sequencing and analysis.

Experience with membrane proteins and/or cell-free expression will be regarded as a plus.

Profile 2

Recent Ph.D. in computational protein design or modelling.

Demonstrated experience in:

  • Modelling/design of protein with Rosetta, AlphaFold and/or deep learning.
  • Deep sequencing data analysis and interpretation.
  • Good understanding of (membrane) protein structure.

The two candidates will collaborate and should therefore have excellent verbal and written English communication to facilitate inter-disciplinary work.

We offer
  • State-of-the-art structural biology, computing, and protein engineering facilities
  • Excellent training in academic, technical, and career skills.
  • A stimulating and supportive international research environment.
  • VIB provides competitive salary and benefits, as well as participation in national social security, healthcare, and retirement plans.
  • Starting date: April 2024
How to apply?

Interested candidates should submit their candidacy through the VIB online application tool.

A complete application file (English) should contain the following documents:

  • your cover/motivation letter stating career goals, past experience, and how these relate to the current position
  • your CV
  • contact information of 2 references

For further information and questions, please send an email to Anastassia Vorobieva (anastassia.vorobieva@vib.be). 

Company

VIB’s core mission is to generate disruptive insights in the molecular underpinning of life and to translate these actively into impactful innovations for patients and society. VIB is an independent research institute where some 1,800 top scientists from Belgium and abroad conduct pioneering basic research. As such, they are pushing the boundaries of what we know about molecular mechanisms and how they rule living organisms such as human beings, animals, plants, and microorganisms. Based on a close partnership with five Flemish universities – Ghent University, KU Leuven, University of Antwerp, Vrije Universiteit Brussel, and Hasselt University – and supported by a solid funding program, VIB unites the expertise of all its collaborators and research groups in a single institute. VIB’s technology transfer activities translate research results into concrete benefits for society such as new diagnostics and therapies and agricultural innovations. These applications are often developed by young start-ups from VIB or through collaborations with other companies. This also leads to additional employment and bridges the gap between scientific research and entrepreneurship. VIB also engages actively in the public debate on biotechnology by developing and disseminating a wide range of science-based information. 

More info can be found on www.vib.be.

Company info
Website
Telephone
09446611
Location
Rijvisschestraat 120
 Zwijnaarde
Belgium
9052
BE
Apply on website (This will open in a new window from which you will be automatically redirected to an external site after 5 seconds)
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