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Postdoctoral Research Scientist- Profs. Jim Norman and Martin Bushell

Employer
CRUK Scotland Institute
Location
Glasgow City (GB)
Salary
from £37,000 to £44,852 subject to experience, plus relocation allowance and visa costs if required
Closing date
9 Aug 2024

View more

Discipline
Health Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Charity/NGO

Elucidating how coordination of mRNA-translation and membrane trafficking influences tumour initiation in the liver

Salary: from £37,000 to £44,452 subject to experience, plus relocation allowance and visa costs if required.

Contract term: Fixed up to 6 years, subject to successful review at Year 3

About us

The CRUK Scotland Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.

Project outline

We are recruiting 2 post-doctoral research scientists to work on an ambitious project funded for 5 years by an MRC Programme Grant. The project is focussed on investigating how regulation of the mRNA translation machinery influences initiation of hepatocellular carcinoma. We have found that that increased rates of mRNA translation and protein synthesis can, paradoxically, restrain tumour initiation and that this is, in part, due to the influence of this on membrane trafficking events such as endocytosis (Moore et al. bioRxiv 2023.08.16.553544).

The scientists engaged on this project will use in vivo, ex vivo and in vitro approaches to investigate the cellular and molecular mechanisms through which mRNA translation rates alter Golgi-transport, endocytosis and endocytic sorting in hepatocytes. Furthermore, this will involve determining how such altered membrane trafficking can favour establishment of tumour initiation niches via regulation of extracellular matrix deposition in the liver. 

This programme will also involve state-of-the-art cryo-EM tomography to visualise molecular details of the relationship between the mRNA translation and membrane trafficking machineries. This ultrastructural arm of the project will be conducted by a 3rd post-doctoral scientist (also funded by the MRC Programme) located in the laboratory of Dr Stephen Carter at the Centre of Virus Research at the University of Glasgow.

To be considered for these positions you will have successfully (or nearly) completed a PhD in a relevant field with experience in molecular and/or cell biological approaches being essential. The project will involve working with murine models of liver disease and cancer. Thus, a willingness to learn and apply these in vivo approaches is essential (appropriate training will be provided), and previous experience with murine models of disease would be useful. The project will also involve ribosome profiling/foot printing and sophisticated proteomic (pulse-chase SILAC) approaches for which training will be provided and previous exposure to these methods would also be an advantage. 

Successful candidates will be strongly motivated by discovery science and to drive experimental work which increases our understanding of fundamental biological mechanisms influencing disease. The desire to work as part of a team to achieve this will essential. 

For informal enquiries, please email:

Prof. JC Norman: j.norman@crukscotlandinstitute.ac.uk

Prof. Martin Bushell: Martin.Bushell@glasgow.ac.uk

Dr. Stephen Carter (for enquiries related to cryo-EM): Stephen.Carter@glasgow.ac.uk

Postdoc support

Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:

Exciting, innovative cancer research projects in state-of-the art labs A highly collaborative and interactive research environment Access to and training in key advanced technologies, for example imaging and in vivo modelling A mentor enabling scheme to aid personal and professional development A rich programme of scientific exchange through seminars, workshops and meetings Support to make fellowship and small grant applications, including during their transition to their next position Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry. A highly engaged postdoc forum, providing peer support, training, careers advice and regular social events Equality, Diversity and Inclusion

Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.

The Institute is also committed to increasing the number of female scientists at the postdoc level and beyond and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children amongst other family friendly policies 

Employee Benefits

 

  • Competitive salary 40.5 days annual leave including bank holidays (pro-rata) Defined Contribution pension scheme Life Insurance scheme Employee Assistance Programme Season ticket loan Additional maternity pay at 6 month’s full pay (subject to service) Shared parental leave Cycle to work scheme that could save you 26-40% on a bike and accessories. Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more. On-site secure parking

All applications must be made via our website at:

https://www.crukscotlandinstitute.ac.uk/careers/postdoctoral-fellows.html

Closing Date: 9th August 2024.

 

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