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Postdoc Research Fellow - Adoptive T Cell Immunotherapy

Employer
Fred Hutchinson Cancer Center
Location
Seattle, Washington State
Salary
$67,728 to $100,000
Closing date
6 Sep 2024

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Discipline
Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Charity/NGO

Job Details

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.


With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.


At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

 

The Post-Doctoral Research Fellow will work on independent and collaborative projects in Dr. Chapuis' laboratory developing adoptive T cell immunotherapy within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Center. This highly translational research will involve the development of novel TCR-based cellular therapies for clinical translation; development of next-generation humanized murine models to gain insights into the in vivo barriers to effective therapy; and may include monitoring patients through-out the course of treatment with T cell therapies.  Additionally, the successful applicant will employ strategies for improving current immunotherapy treatments, including and not limited to; cloning and characterizing T cell receptors (TCRs) specific for cancer-associated antigens, developing cutting-edge strategies for genetic modification of human T cells including CRISPR-based gene editing, and developing/testing new approaches for overcoming immunosuppressive signals in the tumor microenvironment.

 

Dr. Chapuis is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. This is a full-time position. Please note that WA state has mandated minimum salary for overtime-exempt employees (WAC 296-128-545).

 

Responsibilities

  • Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections
  • Molecular bench work with PCR, cloning, and vector design
  • NGS including, Single cell RNA sequencing, WEX, WGS
  • Validation through functional and killing assays
  • Write and submit grants and first author papers to peer reviewed journals
  • Stay current with relevant publications and apply knowledge to research
  • Compile data and synthesize innovative problem-solving methods
  • Collaborate and present data with a wide range of stakeholders and partners
  • Train others on protocols
  • Mentor and lead undergraduate and graduate students
  • Assist with lab maintenance and function

 

Qualifications

MINIMUM QUALIFICATIONS:

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology
  • Proficient in immunology technique and knowhow
  • Strong scientific writing skills, ability to write and apply for funding opportunities and abstracts
  • Able to digest complex material and synthesize innovative ideas
  • Compile and clearly present data to an eclectic audience, both orally and written
  • Well versed in flow cytometry

PREFERRED QUALIFICATIONS:

  • Experience with molecular techniques lentiviral modification of T cells
  • Experience in analysis of TCR signaling pathways and T cell function
  • Familiarity with biostatistics, R and Python languages
  • Ability to derive and maintain T cell tissue cultures
  • Have a good understanding of SRAs and/or phase I/II clinical trials

 

The annual base salary range for this position is from $67,728 to $100,000 and pay offered will be based on experience and qualifications.

 

Company

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit of, and passion for, health knowledge and hope to their work and the world. Together, our researchers are discovering new ways to detect cancers earlier, when cure rates are highest; developing effective treatments with fewer side effects; and learning how to prevent cancers from growing in the first place.

Our groundbreaking discoveries began in the 1970s with Dr. E. Donnall Thomas’s pioneering work in bone marrow transplantation, which led to him receiving the 1990 Nobel Prize in physiology or medicine. Since then, Hutch researchers have made a number of breakthroughs, including developing immunotherapies that use the immune system to defeat cancer and advancing the understanding of human biology. 

Admittedly, the eradication of cancer and other life-threatening diseases is an ambitious goal, one that demands tenacity, scientific excellence, collaboration and breakthrough creativity. To accomplish this, Fred Hutch attracts some of the world's greatest minds.

Our roster of internationally acclaimed scientists includes a MacArthur fellow, members of the National Academy of Sciences, members of the Institute of Medicine, members of the American Academy of Arts and Sciences, members of the American Association for the Advancement of Science and current and former Howard Hughes Medical Institute investigators.

Fred Hutch understands that disease research means more than searching for new treatments. We are home to the country's largest and oldest cancer prevention program, which has made key contributions to understanding how diet, exercise and other factors reduce the risk of acquiring the disease.

To accelerate our progress, we are part of the Fred Hutch / University of Washington Cancer Consortium. This research and clinical collaboration between the Hutch, the University of Washington, Seattle Children’s and Seattle Cancer Care Alliance enables our researchers to leverage each institution’s strengths and develop premier research programs across many types of disease. The Consortium is among 49 National Cancer Institute-designated comprehensive cancer centers nationwide.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Company info
Location
Seattle
WA
98109
United States

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