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Post-doctoral researcher; Chromatin Remodeling, DNA repair and Epigenetics Team

Villejuif (Ville), L'Haÿ-les-Roses (FR)
To be determined in accordance with the Salary Regulations for Fixed Term Employees
Closing date
2 Sep 2024

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Biomedicine, Health Science
Job Type
Employment - Hours
Full time
Fixed term

Position: Post-doctoral researcher
Location: Gustave Roussy, Villejuif, France
Duration: 3 years, available now
Employeer: Gustave Roussy

We are seeking for a highly motivated post-doctoral researcher to join the team of Sophie Postel-Vinay at Gustave Roussy, to work on an exciting project studying chromatin remodeling defects in cancer, selected for funding by the European Research Council (ERC). Context : The Chromatin Remodeling, DNA repair and Epigenetics Team, led by Dr Sophie
Postel-Vinay as part of the Gustave Roussy Inserm Unit U981, aims to investigate synthetic lethal interactions as new therapeutic strategies for tumours defective in DNA repair or epigenetic processes. Our team closely collaborates with the Drug Development Department and the sarcoma committee, to validate the predictors and implement new targets in
therapeutic trials. The candidate will be supervised by S. Postel-Vinay and have the opportunity to work in an extremely dynamic and collaborative research environment at Gustave Roussy, one of the leading cancer research centers in Europe, in close collaboration with other French and international excellent institutions, notably University College of London.

Objectives: The aim of the project is to study chromatin remodeling defects in cancer. The successful candidate will be responsible for designing and executing experiments to explore chromatin remodeling in selected tumor types, using preclinical models and molecular data from patients tumor samples.

Required skillset: Applicants are expected to have the following:
• Background in epigenetics: experience in techniques such as ChIP-Seq, ATAC-Seq, RNA-Seq, Cut&Tag or Cut&Run
• Experience in single-cell technologies
• Background in molecular biology and genome editing (e.g. CRISPR-Cas9)
• Experience in bioinformatics and analysis of NGS or single-cell data (or willing to learn such analyses)
• Strong publication track-records
• Excellent communication skills
• Independence

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