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Postdoctoral Research Fellows - Sensory Ion Channels, Cordero-Vásquez Research Group at UTHealth

Employer
Julio Cordero Morales, PhD
Location
Houston, Texas (US)
Salary
Competitive
Closing date
25 Aug 2024

View more

Discipline
Applied Science, Health Science, Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Academia

Research Positions available in Houston, TX, United States: 

- Postdoctoral Research Fellows

Cordero-Vásquez Research Group at UTHealth

Our research group is a member of the Department of Biochemistry and Molecular Biology at UTHealth Houston, located in vibrant Houston, TX. A postdoctoral position is currently available in our group. Experience in biochemistry/protein purification and cryo-electron microscopy is required. Highly motivated individuals are encouraged to email us a CV and three references' names and contact information.

Group members can expect individualized mentorship, a team-oriented environment, and the opportunity to interact with talented faculty across the Texas Medical Center. All work is supported by recently awarded federal and institutional funding.

Our major scientific focus is on the regulation of sensory ion channels:

1. The modulation of transient receptor potential (TRP) channels by membrane lipids

This project aims to understand how various membrane lipids contribute to the function of TRP channels in normal and pathophysiological conditions. Selected work:

Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Reports. doi:10.1016/j.celrep.2022.111306.

Deficiency of inositol monophosphatase activity decreases phosphoinositide lipids and enhances TRPV1 function in vivo. J Neurosci. doi:10.1523/JNEUROSCI.0803-20.2020.

2. Fatty acids and mechanosensitive ion channel function

Our laboratories focus on exploring the mechanisms underlying the various effects that fatty acids have on mechanosensitive ion channels (i.e., mammalian PIEZOs, PEZO1, and bacterial channels) and their potential use to ameliorate neurological disorders. Selected work:

Linoleic acid improves PIEZO2 dysfunction in a mouse model of

Angelman Syndrome. Nat Commun. doi:10.1038/s41467-023-36818-0.

A dietary fatty acid counteracts neuronal mechanical sensitization.

Nat Commun. doi:10.1038/s41467-020-16816-2.

3. Roles of PEZO1 function in C. elegans physiology

PEZO1 is a mechanosensitive ion channel expressed in C. elegans, whose function is widely unknown. We are working to uncover novel physiological roles of PEZO1. Additionally, we are using this model to learn more about the functional consequences of mammalian diseases. Selected work:

C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation. J Gen Physiol. doi: 10.1085/jgp.202112960.

 

Contact: Julio Cordero-Morales – julio.corder@uth.tmc.edu             Valeria Vásquez – valeria.vasquez@uth.tmc.edu

More information can be found at our website https://www.corderovasquezlab.com and @CVResearchGroup

 

 

 

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