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PhD student

Employer
Oslo University Hospital, Department of Microbiology
Location
Oslo (By), Østlandet (NO)
Salary
approx 48 000 Euro
Closing date
28 Jul 2024

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Discipline
Health Science
Job Type
PhD Position
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Hospital

A 3-year full time PhD position is available for an ambitious and motivated candidate, in the group headed by Dr. Deo Prakash Pandey (https://www.ous-research.no/pandey/). We are seeking a candidate with strong motivation and interest in cancer epigenetics, i.e., how chromatin and epigenetic alterations contribute to transcriptional aberrations and genome integrity in cancer.

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

Tasks/expectations

The success candidate will work on one or more well-funded projects and will have the freedom to develop his/her ideas into new projects under the overarching theme of cancer epigenetics with a focus on brain tumors. The projects often involve use and implementation of many complex genomic and chromatin technologies together with quantitative microscopy and flow cytometry methods, and it is expected that the candidate can function in a collaborative manner by taking efficient help from the support network of core facilities and collaborators.

 

Job Qualifications

The applicant should have a master’s degree with a strong background in experimental molecular cell biology (cell culture and standard molecular biology skills) in the field of cancer biology or stem cell biology. Experience and know-how of working on projects involving high throughput sequencing and integrating various multi-omics approach will be a huge plus. Candidates with experiences involving quantitative approaches using microscopy and flow cytometry methods will be prioritized.  Applicants with excellent work ethic, ability to multitask, and mentoring skills (ability to supervise and work with master students) will be given preference.

Education level

 

Master’s degree in eukaryotic molecular cell biology.

 

Experimental skills

Experience and know-how of cell biology and biochemical approaches and exposure to the high throughput sequencing based approaches will be a strong plus. Whereas prior knowledge of these approaches is hugely advantageous, it is not a strict requirement, what we seek is the drive to learn and implement new combination of experimental and computational approaches in cancer epigenetics.

 

 

Background on the project description

The main goal of our research is to advance the understanding of molecular mechanisms contributing to cancer and to identify and characterize novel dependencies which can be used to target cancer in patients. For a cancer model, we focus on tumors of central nervous systems which are some of the worst malignancies that afflict mankind. We use clinically relevant mouse in vivo and in vitro GBM models to study gliomagenesis and validate our findings in the primary human glioma neural stem (GNS) cells derived from GBM patients. The mouse and human GBM cellular models are derived from neural stem cells and the characterization of genes required for their proliferation is a major focus of our research.

 

Aside from standard molecular biochemistry approached, we apply RNAi and CRISPR/Cas9 technology to carry out loss-of-function experiments and to edit endogenous loci in the genome. Furthermore, we use a variety of high-throughput sequencing to study gene regulation including RNA-seq/SLAM-seq, ChIP-seq, CUT&RUN/TAG. Exposure to these technologies will be a strong plus, but these are already implemented in the group and a driven and committed candidate can easily adapt to them quickly. For a latest manuscript from our group, please see: https://doi.org/10.1101/2023.07.14.548985

 

 

 

Languages

 

Excellent English written and verbal communication skills are required.

 

 

 

The location

 

We are located at the SINTEF building Oslo University Hospital, campus Rikshospitalet adjacent to a hilly forest suitable for short walks/hikes. Oslo (and entire Norway) is consistently ranked as one of the places in the world to live in.

 

 

 

We offer

 

  • An ambitious and exciting research theme in a stimulating scientific environment with excellent opportunities for academic development A strong collaborative network with highly competent core facilities and a strong international outlook Full-time three-year position Attractive salary according to the guidelines from the Oslo University Hospital Favorable pension arrangements Attractive family-welfare arrangements, with affordable high-quality childcare

 

 

Interested persons should submit the following documents:

 

1) Single-page application letter (Summary of scientific work and motivation for applying).

 

2) Curriculum vitae (summarizing education, positions and other qualifying activity).

 

3) List of publications (Submitted manuscripts including on bioarxiv can be included).

 

4) Copies of educational certificates with grades

 

5) Contact information of three references must include former coworkers and supervisors (name, email address, affiliation, phone number and relation to the candidate).

 

 

 

Applications must be submitted through the formal recruitment website WebCruiter.

 

Any questions regarding the position can be directed to:

 

 

 

Principal Investigator Dr. Deo Prakash Pandey     

 

Email:   deo.prakash@gmail.com; deopan@ous-hf.no

 

Phone: +47 48595077

 

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