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Postdoc or PhD position: the biology of microglia in neuroinflammatory disease

Employer
French National Institute for Health Research (INSERM)
Location
Paris, Ile-de-France (FR)
Salary
The salary will be according to experience following INSERM regulation.
Closing date
19 Aug 2024

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Discipline
Life Science
Job Type
PhD Position, Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Academia

Job Details

Neurodegenerative and neuroinflammatory diseases are increasingly frequent. They often involve peripheral immune cells that infiltrate the CNS and tissue-resident cells, among which microglia are particularly important. Microglia act as drivers of pathogenesis, yet also have crucial beneficial activities in these diseases, controlling the resolution of inflammation and CNS regeneration.

 

The goal of this project is to map the molecular networks controlling the fate of microglia towards these antagonistic activities using a mouse model of multiple sclerosis, and to functionally validate the core genes controlling these molecular networks in vivo. This will be achieved using scRNAseq, spatial transcriptomics, advanced machine learning approaches, and genetic approaches to manipulate the expression of candidate genes in microglia in vivo.

 

To meet this goal, the project will capitalize on a cell-therapy approach recently developed in the team, which makes use of pure and stable IL-10-producing B cells and cures recipient mice from disease within a few days by targeting microglia.

 

             These studies will provide a starting point to then address whether the molecular processes identified are relevant in Human diseases including in multiple sclerosis.

 

Collectively, these investigations will provide important knowledge to envision the manipulation of microglia to resolve neuroinflammation and promote neuro-regeneration in order to restore health during CNS diseases.

 

INEM is a biomedical research center including 19 teams and two departments: “Cell Biology (Growth and Signaling)” and “Immunology, Infectiology, and Haematology”. Together with the IMAGINE institute and the Hôpital Necker-Enfants Malades, it makes up the Necker campus which, supported by state-of-the-art core facilities, provides a vibrant environment for basic research and translational innovation. The Campus has a long-standing reputation for scientific excellence (8 principal investigators (PIs) at INEM received ERC awards) and key pioneering medical contributions (e.g. transplantation, biotherapy, gene therapy).

 

 

 

The position is funded for a post-doctoral scientist (2 years) or a PhD (3 years).  

 

 

Salary will be according to experience following INSERM regulation.

 

 

 

Please send your application via email in English with CV, a brief outline of previous research, and contact details of three references to: simon.fillatreau@inserm.fr ; simonfillatreau@googlemail.com

 

 

 

Simon Fillatreau

 

INEM- Team – Immunity in Health and Disease

 

156-160, rue de Vaugirard, 75015 Paris, France

Company

Founded in 1964, Inserm is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. Inserm brings together 15,000 researchers, engineers, technicians and administrative staff, all with one shared objective: improve health by advancing knowledge about living organisms and diseases, developing innovative treatment modalities and conducting research on public health.

Company info
Website
Telephone
+33144236277
Location
101 Rue de Tolbiac
Paris
Paris
75013
FR

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