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Postdoc to investigate molecular mechanisms in the field immune-rejuvenation for drug discovery

Sentcell LTD
Toscana Life Sciences, within the GSK Campus, Siena, Italy
excellent career progression with competitive salary plus bonuses
Closing date
16 Aug 2024

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Life Science
Job Type
PhD Position, Postdoctoral
Employment - Hours
Full time
Fixed term

In the compelling and unstoppable research in favor of cellular rejuvenation, Sentcell LTD is looking for PhD or Postdoc Researchers to investigate molecular mechanisms and innovative therapies at basis of T cell and systemic rejuvenation. The studies will be held at our new laboratory located at the Toscana Life Sciences, within the GSK Campus, in Siena, Italy.

Expertises required will span across:

a) Flow cytometry
b) In vivo studies
c) Immunoblotting/Immunoprecipitation
d) Elisa assays
e) PCR
f) Primary culturesBioinformatic skills are strongly appreciated (docking predictions).

The ideal candidate will possess:
• Degree in Biology, or Biotechnology, or Medicine or other Biological Sciences
• Completed or about to complete
PhD in Cellular/Molecular Biology or Molecular Medicine or Immunology
• Excellent level of spoken and written English
• Team working skills

The candidate, preferably with work experience abroad, will have in depth understanding in the field of Immunology and/or Biochemistry with particular regard to signal transduction.

The candidate(s) will be offered:
• A competitive three-year contract commensurate to track record
• Excellent career progression prospects with important salary adjustments and bonuses
• Opportunities for professional growth of the highest level

Sentcell LTD was founded by Prof. Dr Alessio Lanna in the UK back in 2019, and has rapidly been recognised at the top of all biotech companies operating in the country.

Sentcell first of its kind work started from the understanding that T lymphocytes, particularly CD4+ cells,  are at the pinnacle of the aging process in all organs. Despite so, no T cell rejuvenation therapies presently exist and Sentcell is committed to fill in the gap.We were the first to discover the "sMAC" macromolecular complex, responsible for the cellular aging program of T lymphocytes (Lanna et al., Nature Immunology, 2014 and Lanna et al., Nature Immunology 2017), and a new anti-aging mechanism based on transfer of telomeres in vesicles between immune cells (Lanna et al., Nature Cell Biology, 2022).

On this basis, we introduced the "DOS", which- to date- represents the first drug in the world capable of reversing T cell aging resulting in immune remodelling as well systemic rejuvenation as a whole, via both sMAC disruption and telomere transfer induction (Lanna et al., under consideration)
In the near future, these T cell rejuvenating approaches will span to fight variety of diseases across the organism.

A first in human clinical trial of DOS will be held in the UK in 2025; as such candidates will be exposed to an extraordinary work flow spanning from target identification to drug discovery and in human medical translation to treat human diseases.





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