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Postdoctoral Researcher Positions in Host-Microbiota/Pathogen Interaction

Employer
French National Institute for Health Research (INSERM)
Location
Paris, Ile-de-France (FR)
Salary
The postdoctoral salary is in accordance with the applicant’s previous research experience.
Closing date
16 Aug 2024

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Discipline
Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

Job Details

The laboratory of Host-Microbiota Interaction, directed by Pamela Schnupf, at INEM in central Paris, France, is recruiting two postdoctoral  researchers for three years on the ERC CoG-funded project NicheAdapt. The laboratory focuses on the characterization of the unique niche adaptations and interactions of the unusual commensal bacterium Segmented Filamentous Bacteria (SFB) with its host. SFB is highly unusual Clostridium-related commensal that is ubiquitously found in vertebrates and potently affects the host immune system. SFB has the atypical feature of intimate attachment to the host ileum, a normally pathogenic feature, without inducing pathology. The potent SFB-elicited immune stimulation promotes the postnatal development of intestinal lymphoid tissue and induces a state of physiological inflammation characterized by a strong Th17 cell response and enhanced colonization resistance to pathogens. Our work uses a combination of wild-type and knock-out gnotobiotic mouse models, in vitro hypoxic growth conditions and a variety of “omics”.

We are interested in better deciphering the life-cycle and the unusual attachment of the bacterium to its host as well as the bacterial and host factors involved. This work will give critical insights into the cross-talk between the host and the gut microbiota and will address unknown features of the unusual life-cycle of SFB and mechanisms underlying gut immune homeostasis.

We are interested in recruiting two candidates. The lab has several projects requiring varying expertise. We encourage applications from candidates that have any of the following expertise:

  1. a background in host-pathogen interaction or immunology/mucosal immunology and cell biology. Technical expertise in gnotobiology could be advantageous
  2.  a background in bioinformatic analysis of bacterial metagenomic data and bacterial genome assembly and annotation.
  3. a background in cryo electron microscopy. Technical expertise in biochemistry, molecular biology and tissue culture could be advantageous.

 

 

Company

Founded in 1964, Inserm is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. Inserm brings together 15,000 researchers, engineers, technicians and administrative staff, all with one shared objective: improve health by advancing knowledge about living organisms and diseases, developing innovative treatment modalities and conducting research on public health.

Company info
Website
Telephone
+33144236277
Location
101 Rue de Tolbiac
Paris
Paris
75013
FR

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