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Postdoc and technician in neurodegenerative disease

Employer
Department of Neurology UCLA
Location
Los Angeles, California
Salary
$64480-$77327
Closing date
13 Aug 2024

View more

Discipline
Biomedicine, Health Science
Job Type
Postdoctoral, Research Assistant
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

Multiple postdoc and technician positions are available in the laboratory of Dr. Chao Peng at the Department of Neurology at University of California, Los Angeles (UCLA). Peng lab focuses on the molecular and cellular mechanisms of alpha-synuclein and tau-related neurodegenerative diseases including but not limited to Parkinson’s disease, Alzheimer’s disease, and multiple system atrophy. We develop cutting-edge disease models and apply powerful genetic, multi-omics, system biology, and high throughput screen methods to investigate a wide range of topics related to the development and progression of these diseases. We are particularly interested in the transmission, conformational diversity, and biological consequences of pathological proteins in neurodegenerative diseases and the role of neuron-glial interactions in disease etiology. We also work with companies and academic collaborators to develop novel therapeutic strategies for neurodegenerative diseases. Our publications are well-recognized by the neurodegenerative disease community including Nature, Nature Neuroscience, and Nature Reviews Neurology. The laboratory environment is highly collegial and interactive. 

 

UCLA has been ranked the No.1 public school in the US by U.S.News in 2024. The rich scientific environment provides unparalleled research training opportunities, including research seminars given by scientific leaders around the world, exposure to diverse research programs, cross-disciplinary collaborations, and a large amount of highly sophisticated core facilities.

 

Successful candidates for postdoc positions are expected to have a PhD degree with a strong record of publication and should be highly motivated, collaborative, and able to conduct independent research. Candidates with a strong background in biochemistry, stem cell, metabolism, or neuroscience are particularly encouraged to apply. These are fully funded multi-year positions. A highly competitive salary ($64480-$77327) will be provided and commensurate with experience.

 

Application should be sent to Dr. Chao Peng (cpeng@mednet.ucla.edu). Please include your detailed curriculum vitae, a statement of research interests describing your background and research interest, and the contact information of three references.

 

 

 

Selected Reference:

 

1. Zhang, S., Zhu, R., Pan, B., Xu, H., Olufemi, M., Gathagan, R., Li, Y., Zhang, L., Zhang, J., Xiang, Q., Kagan, E., Cao, X., Yuan, C., Kim, S., Williams, C., Magaki, S., Vinters, H., Lashuel, H., Garcia, B., Petersson, J., Trojanowski, J.Q., Lee, V.M.,* Peng, C.* (2023) Post-translational Modifications of Soluble α-Synuclein Regulate the Amplification of Pathological α-synuclein. Nature Neuroscience doi:10.1038/s41593-022-01239-7 (* co-corresponding)

 

 

2. Peng, C., Gathagan, R.J., Covell, D.J., Medellin, C., Stieber, A., Robinson, J.L., Zhang, B., Pitkin, R.M., Olufemi, M.F., Luk, K.C., et al. (2018). Cellular milieu imparts distinct pathological alpha-synuclein strains in alpha-synucleinopathies. Nature 557, 558-563. PMCID: PMC5970994

 

3. Peng, C., Trojanowski, J.Q., and Lee, V.M. (2020). Protein transmission in neurodegenerative disease. Nat Rev Neurol 16, 199-212.

 

4. Pan, C. & Peng, C. (2022) LRP1: a novel receptor for the transmission of pathological alpha-Synuclein. Molecular Neurodegeneration 17, 79, doi:10.1186/s13024-022-00582-4. PMCID: PMC9701376

 

5. Henderson, M.X., Sedor, S., McGeary, I., Cornblath, E.J., Peng, C., Riddle, D.M., Li, H.L., Zhang, B., Brown, H.J., Olufemi, M.F., et al. (2020). Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological alpha-Synuclein Insult. Neuron 105, 822-836 e827. PMCID: PMC7060125

 

 

 

 

UCLA is an Equal Opportunity Employer.

 

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