Postdoctoral Scholar

Postdoctoral Scholar

The Paczesny laboratory is seeking highly motivated candidates for a post-doctoral fellowship studying immunotherapy including allogeneic hematopoietic cell transplantation to treat leukemia. The major interests of the lab are in proteomics and biomarkers, graft-versus-host disease and graft-versus leukemia, tumor immunology, novel immunotherapies including cell-based and small molecules, and understanding the alarmin IL33/ST2 axis during inflammatory diseases. In this position, you will have the opportunity to develop and lead projects using several cutting-edge model systems including novel bone marrow transplantation, and xenograft in vivo systems, and primary patient samples. You will also gain extensive experience and training in proteomics, leukemia models, and hematopoietic stem cell transplantation pre-clinical models.

Job Duties:

50% - Develop and lead projects using several cutting-edge model systems including hematopoietic cell transplantation and novel xenograft in vivo systems, and primary patient samples. Each project leading to a presentation at a national meeting as well as manuscript of impact factor > 6. - (Essential)

25% - Perform immunology techniques including ELISAs, flow-based cytokine determination, cellular proliferation and cytotoxicity assays including for collaborative work on multi-institutional grants. - (Essential)

20% - Train in proteomics, hematopoietic cell transplantation biology, and pre-clinical study development. Similarly the outcomes will lead to a publishable manuscript - (Essential)

5% - Perform other essential duties as requested. These will include maintain animal colonies, collaborate with DLAR to provide the best animal care, update IACUC and IBC protocols, order supplies for the laboratory. - (Essential)

Preferred Experience & Additional Skills: Successful applicants will have a Ph.D. or M.D./Ph.D. with substantial hands-on research experience in immunology; a strong publication record in recognized peer-reviewed journals; experience with animal models of cell adoptive transfer, bone marrow transplantation and/or leukemia is required; experience with multicolor flow cytometry and in immunology techniques including ELISAs, flow-based cytokine determination, cellular proliferation and cytotoxicity assays; be meticulous at planning, executing, and organizing the results for large scale assays. Must also be capable of taking initiative, work independently and in a collaborative setting. Excellent written and verbal communication skills are required, as are excellent organizational skills and knowledge of proper scientific record keeping as well as being comfortable in a fast-paced environment and able to adjust workload based upon changing priorities.

MUSC:

The Medical University of South Carolina (MUSC) is located in the beautiful historic district of Charleston (ranked #1 travel destination in the U.S.) bounded by the Atlantic Ocean and beautiful beaches to the east, and national forests and wildlife refuges to the north and south. MUSC is the state’s top-ranked medical center. The Medical University of South Carolina is a leading medical research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future.

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations.

Application materials should be addressed to:

Sophie Paczesny, MD, Ph.D.

Professor of Microbiology and Immunology and Pediatrics

Hollings Cancer Center Biology & Immunology Program co-Leader

SmartState Endowed Chair, Cancer Stem Cell Biology

Medical University of South Carolina

86 Jonathan Lucas, Rm HO612E

Charleston, SC 29425

843-792-1034 

paczesns@musc.edu