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PhD student or Postdoc positions (f/m/d) in the field of Molecular Oncology

Employer
University of Würzburg - Biocenter
Location
Würzburg (Stadt), Bayern (DE)
Salary
Salary according to TV-L E13
Closing date
28 Jul 2024

View more

Discipline
Biomedicine, Chemistry, Life Science
Job Type
PhD Position, Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Academia

The research group of Prof. Martin Eilers at the Biocenter Würzburg is interested in MYC oncoproteins that drive the growth of many human cancers. We are now offering two

 

PhD student or Postdoc positions (f/m/d)

 

to work on wet-lab projects aimed at the structural and functional characterisation of critical complexes of the MYCN oncoprotein. MYCN is a member of the MYC protein family that drives the growth of childhood tumours. The projects will use a combination of AI-based structural prediction, protein purification and crystallisation to characterise these complexes. The projects will be in collaboration molecular biologists at the Biocenter who are using a wide range of molecular biology and in vivo techniques to characterise MYCN-driven tumourigenesis. Both scientists will be part of the Cancer Grand Challenge KOODAC team (https://cancergrandchallenges.org/teams/koodac), an international team that aims to develop new degrader molecules ('Protacs') for oncoproteins that drive childhood cancers. The projects will be carried out in close collaboration with leading structural biologists, cancer biologists and drug developers at several academic centres worldwide. For more information about the group and the KOODAC team, please visit: https://www.biozentrum.uni-wuerzburg.de/en/molbio/ or contact us (bz-molbio@uni-wuerzburg.de).

 

Our offer

  • Cutting-edge research in an established group
  • Close collaboration as part of an international team of leading groups that together tackle a major question in cancer research
  • Excellent networking and collaboration opportunities at the Biocentre Würzburg, the Comprehensive Cancer Centre, the University Hospital, the Max Planck Institute for Systems Immunology and the Mildred Scheel Nachwuchszentrum (MSNZ) for Cancer Research
  • Full-time appointment for 3-years, salary (TV-L E13), fixed-term, extension possible
  • For the PhD student: Enrolment in the Graduate School of Life Science with broad research and skills training

 

Tasks

  • Analyze the structure of critical protein complexes of the MYCN interactome using a combination of structure prediction and wet lab experiments
  • Validate the function of these complexes in neuroblastoma cells using state-of-the-art sequencing methods and multiple cell biological assays
  • Co-operate with tumor biologists for in vivo studies
  • Presenting your results at meetings and conferences

 

Your profile

  • Excellent Master or PhD degree in biology, biomedicine, biochemistry, chemistry, or pharmacology
  • Previous wet lab experience in one of these fields as a master or PhD student
  • Fluency in written and spoken English
  • Ability to work independently and collaboratively within the group
  • Prior knowledge in bioinformatics is advantageous but not obligatory.

 

We welcome applications from suitably qualified people regardless of race, gender or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to people with disabilities in the case of otherwise equal aptitude. Working language is English, knowledge of the German language can be beneficial, but is not required.

 

Please send your application (CV, letter of motivation, relevant degree certificates and academic transcripts as well as contact details of two independent references) as a single PDF file via email to

 

Prof. Dr. Martin Eilers

Attn. Monika Reichert

E-mail: bz-molbio@uni-wuerzburg.de

 

Application deadline: July 31st  2024

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