Skip to main content

Postdoctoral Research Scientist in Union - Molecular Medicine

Employer
Columbia University - Department of Medicine/Division of Molecular Medicine
Location
New York City, New York (US)
Salary
$71,050 with benefits
Closing date
21 Jul 2024

View more

Discipline
Biomedicine
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Academia

Columbia University’s Department of Medicine invites applications for a research position in the rank of Postdoctoral Research Scientist (in Union) at The Columbia University Irving Medical Center in the Division of Molecular Medicine (Alan Tall, Director). The position includes both laboratory and translational research.

The Tall laboratory is conducting research on the mechanisms and treatment of cardiovascular diseases.  Our strategy is to use information from human genetic studies to prioritize novel genes and pathways involved in disease pathogenesis for detailed mechanistic studies, which may then suggest new therapeutic targets. As people age, they commonly acquire mutations in hematopoietic genes (called clonal hematopoiesis of indeterminate potential or CHIP). CHIP increases the risk of developing hematological malignancies but also much more commonly atherosclerosis, thrombosis and heart failure. Our research seeks to elucidate the cellular and molecular mechanisms linking CHIP to atherosclerosis and thrombosis. Studies employ mouse models of CHIP, cell fate mapping and single cell RNAseq approaches. Therapeutic approaches involve targeting inflammasomes and inflammatory cytokines.

References

1. Fidler TP et al, The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis, Nature, 2021, PMID 33731931.

2: Liu W et al, Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis. Nature Cardiovascular Research. Vol 2, 2023, 572-586.

3: Tall AR, Bornfeldt KE. Inflammasomes and Atherosclerosis: a Mixed Picture. Circ Res. 2023 PMID: 37228237

4: Yu Z et al, Genetic modification of inflammation and clonal hematopoiesis-associated coronary artery disease. J Clin Invest 2023. PMID: 37498674

5: Fidler TP et al, Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis. Nat Cardiovasc Res. 2024 PMID: 38362011

Required documents

Curriculum Vitae  

Cover Letter

Dissertation Abstract

List of References

Writing Sample/Publication 1

Writing Sample/Publication 2

Research Abstract  

Contacts:

Dr. Alan Tall,  art1@cumc.columbia.edu

Ms. Lilian A. Oling, lao2106@cumc.columbia.edu

Apply for Postdoctoral Research Scientist in Union - Molecular Medicine

Already uploaded your CV? Sign in to apply instantly

Fields marked with an asterisk (*) are required

Your file must be a .doc, .pdf, .docx, or .rtf. No larger than 1MB
Selected file:
Your communication preferences

When you apply for a job we will send your application to the named employer, who may contact you. By applying for a job listed on Nature Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please contact us. All emails will contain a link in the footer to enable you to unsubscribe at any time.

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert

Similar jobs