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Postdoctoral Research Fellow

Employer
Boston Children’s Hospital-Ozcan Lab
Location
Boston, Massachusetts (US)
Salary
Competitive salary and benefits
Closing date
2 Jul 2024

View more

Discipline
Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Academia

 

Postdoctoral Fellow Positions in Harvard Medical School For

Obesity-Related Neuroscience Research

 

 

Two postdoctoral positions are available in the Ozcan Laboratory in the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School.

 

 

 

            The positions are offered to study the role hypothalamic leptin resistance in control of neuron activity, body weight, feeding behavior and metabolic homeostasis obesity. The interested candidates can check our publications in this area to understand the research interests of our lab better:

 

 

 

Ozcan L, et al. Cell Metabolism. 2009 Jan 7;9(1):35-51. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Liu J et al., Cell. 2015 May 21;161(5):999-1011. Treatment of obesity with celastrol. Lee J et al., Nature Medicine. 2016 Sep;22(9):1023-32. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Feng X, et al., Nature Medicine. 2019 March 4-Online publication. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Guan D, et al., Cell Metabolism, 2024. Central Inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.  

 

            The ideal candidates for both positions should have a Ph.D., M.D. or M.D./Ph.D. degrees with strong experience in neuroscience, molecular biology and technical skills to perform intracranial injections evident by peer-reviewed publications in reputable journals. These positions will also include anti-obesity drug development and will provide the fellows opportunity to also learn early drug discovery and development approaches. Highly competitive salary and benefits will be provided.

 

 

 

            Interested candidates should forward their research interests, curriculum vitae along with the name and contact information of three referees to Dr. Umut Ozcan; e-mail: umut.ozcan@childrens.harvard.edu.

 

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