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KOODAC Team Structural Biologist

Employer
Havas People
Location
Dundee City (GB)
Salary
Grade 7 (Spinal Point 29 -36) (£36,024- £44,263)
Closing date
10 May 2024

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Discipline
Biomedicine, Chemistry, Clinical, Health Science
Job Type
Faculty Member, PhD Position, Professor
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Academia

Job Details

Position 3 – Structural Biology / Biophysical Assay Development PDRA (KOODAC team)
Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years
Grade 7 (Spinal Point 29 -36) (£36,024- £44,263)

We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in 
studying structures of protein- ligand and protein-protein complexes to join the group of Professor 
Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted 
Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic, 
multi-disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer 
Grand Challenges, within KOODAC  (https://cancergrandchallenges.org/teams/koodac). KOODAC’s mission 
is to discover and develop small-molecule drugs that degrade key oncogenic drivers of solid tumours 
in children, as a novel therapeutic paradigm to treat pediatric cancers. The team will develop two 
types of degraders – proteolysis targeting chimeras (PROTACs) and molecular glue degraders. Both 
classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce 
target’s ubiquitination and degradation, leading to cell death. The team will focus on developing 
degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) 
oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, 
fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive 
rhabdomyosarcoma, respectively, in children.

Candidate Requirements:
•  A Ph.D. in structural biology, biophysics, biochemistry, chemical / molecular biology, or a 
related discipline
•  Highly experienced in molecular biology (construct design, cloning etc.), protein expression, 
purification and characterisation.
•  Strong experience in structure solution and model refinement via protein X-ray crystallography 
and/or cryo- EM.
•  Outstanding academic and/or industrial track record.
•  Excellent interpersonal, communication and presentation skills.
•  Capable of working in a diverse team, but able to plan and work independently.
•  Exceptional time management, organisational and self-motivational skills.
•  An open and collaborative approach to science.
Preferred skills:
•  Experience with biophysical techniques and assays to study protein-ligand and protein-protein 
interactions are strongly desired.
•  Experience with studying of PROTACs and/or molecular glue degraders.
•  Experience with studying protein-ligand interactions and structure-based drug design.

For further information about this position please contact Professor Alessio Ciulli at a.ciulli@dundee.ac.uk. To find out more about Group please visit the group’s Website.

The Centre for Targeted Protein Degradation is part of a growing Life Sciences Innovation District, 
an ecosystem of organisations and people within the life sciences sector in Dundee driving 
innovation and local economic growth. Opened since January 2023, CeTPD is a first of its kind 
Centre leading a number of internationally significant projects in the burgeoning new area of 
translational chemical biology and targeted protein degradation. The goal of CeTPD is to innovate a 
next-generation of small-molecule technology platforms and modalities to advance chemical and 
biological insights and therapeutic targets related to human diseases. It aspires to achieve this 
by redefining new models of open collaboration with academic, industrial and venture partners, and 
by training and inspiring the next-generation of research scientists and leaders.

The diversity of our staff and students helps to make the University of Dundee a UK university of 
choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff 
networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter 
and Stonewall as well a full range of disability services, create an enjoyable and inclusive place 
to work.
 

Company

Company info
Website
Telephone
+44 784 960 7758
Location
Havas Worldwide London, Unit 1
3 Pancras Square
LONDON
Other / Non-US
N1C 4AG
GB

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