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Director of Cryo-EM Center

St. Jude Children's Research Hospital (St. Jude)
Memphis, Tennessee
Commensurate with experience
Closing date
11 Oct 2024

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Health Science
Job Type
Employment - Hours
Full time

The Department of Structural Biology at St. Jude Children's Research Hospital is seeking an exceptional candidate for the role of Director of the Cryo-EM Center.



The Department of Structural Biology has made substantial investments in state-of-the-art cryo-EM technology and aims to leverage these recent acquisitions to pioneer transformative advancements in structural biology. Recent expansion of the Cryo-EM Center provides the opportunity to acquire additional capital instrumentation, to enhance current capabilities in single-particle analysis (SPA), and to establish innovative cryo-electron tomography (cryo-ET) workflows.


The Cryo-EM Director must have outstanding technological achievements and deep familiarity with state-of-the-art instrumentation. The ideal candidate will command expert knowledge of the cryo-EM field, be knowledgeable about cutting-edge advances, and be compelled by a personal vision for the future of cryo-EM technology developments. Candidates should have significant experience with cryo-EM/SPA and/or cryo-ET.


The Director of Laboratory Operations of the Cryo-EM Center will have a leading role in expanding the Cryo-EM Center and will oversee the acquisition, installation, maintenance, and operation of existing and future equipment. They will establish center-wide policies and workflows for equipment operation and usage.


Under their leadership will be a team of senior scientists whose responsibilities include consulting, training, and assisting St. Jude Children's Research Hospital scientists with their cryo-EM related research. There will be generous support for conference travel as well as professional development. 


Facility directors in the Structural Biology Department at St. Jude Children's Research Hospital enjoy freedom and independence to innovate in methods development and to collaborate with faculty across St. Jude.


Salary and benefit packages are highly competitive and commensurate with experience. Applications will be accepted until the position is filled.


Since its inception in 2017, the Cryo-EM Center has been built up to include: two Titan Krios 300 kV (including new coldFEG Krios G4 equipped with SelectrisX energy filter and a Falcon 4i DED), one 200kV Talos Arctica (equipped with BioQuantum Energy filter and a K3 DED), and a Talos L120C. Moreover, the Center is supported by the high-performance computing facility at St. Jude, with 48 A100 (80GB) GPUs and 40 V100 (16 GB) GPUs dedicated to cryoEM data processing and ample storage. Cryo-ET related equipment includes the Zeiss Crossbeam 550 FIB-milling instrument with a cryo-lift out module, Quorum stage for sample transfer and an LSM 900 microscope with a dedicated Linkham stage for CLEM.


The Department of Structural Biology at St. Jude Children's Research Hospital has undergone remarkable growth and development in recent years, placing itself at the forefront of structural biology and biophysics. With its exceptional Technology Centers and guided by a unique focus on the role of dynamics in driving molecular function, the Department of Structural Biology has outstanding institutional support for its growth and infrastructure. Finally, the Department is committed to scientific excellence by building an energetic, community-minded, collaborative culture and training the next generation of structural biology leaders.


St Jude Children’s Research Hospital is a private, not-for-profit institute that is internationally recognized for its commitment to providing state of the art clinical services, while performing innovative scientific and patient-directed research. It has been consistently rated as one of the 100 best workplaces in the U.S. by Fortune magazine and was recently voted the number one place to work in academia by The Scientist magazine.


This position is based in Memphis, TN with relocation assistance available. Memphis is a family-friendly metropolitan area that is recognized for its world-class music, food, and hospitality. Mild winters and beautiful green spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work.


Minimum Education and/or Training:

  • Bachelor's degree in relevant scientific area is required


Minimum Experience:

  • Twelve (12) years of relevant post-degree work experience is required
  • Ten (10) years of relevant post-degree experience is required with a Master's degree
  • Eight (8) years of relevant post-degree work experience is required with a PhD




In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $114,400 - $216,320 per year for the role of Director of Cryo-EM Center.


Explore our exceptional benefits!



Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.


Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.


St. Jude is an Equal Opportunity Employer


No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

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