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Senior Researcher in Structural Biology – Scott Blanchard Lab

St. Jude Children's Research Hospital (St. Jude)
Memphis, Tennessee
Commensurate with experience
Closing date
11 Oct 2024

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Job Type
Employment - Hours
Full time

Job Details

This is a Senior Researcher opportunity in Structural Biology.



The World’s Brightest Minds Always Innovate

At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.



The Blanchard laboratory in the Department of Structural Biology at St. Jude Children’s Research Hospital is seeking a highly motivated Senior Researcher with experience in molecular biology, biochemistry (preferably of membrane proteins) and quantitative biophysical techniques to investigate the structural dynamics and kinetics of GPCRs and their interaction partners.


Our highly interdisciplinary, collaborative, mission-driven environment requires a creative team-oriented individual with strong leadership skills, who would ensure quality operations and our vision to successfully pursue scientific advances.


In this role, the successful candidate will use protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Expert ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing is essential, as well as passion to learn and navigate new research fields.


The ideal candidate would be a recent PhD graduate (not more than 3 years ago) who is independently able to propose new hypotheses based on available literature, and design experiments and analyze data, with minimum supervision, to test these hypotheses.



  • Design and perform biochemical and biophysical experiments to investigate structure-dynamics-function relationships of various integral membrane proteins or membrane-associated proteins involved in GPCR-mediated signaling pathways.
  • Protein purification, site-specific fluorophore labeling, and biochemical/functional characterization of GPCRs, G-proteins, arrestins, and other signaling proteins.
  • Perform single-molecule fluorescence (smFRET) imaging of labeled signaling molecules with guidance and training from technical experts in the field, analyze smFRET data, and interpret the results in mechanistic, quantitative frameworks with guidance and training from technical experts in the field.
  • Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
  • Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
  • Train and mentor graduate students, post-docs and visiting scientists.
  • Instructs other staff in basic laboratory techniques and procedures.


Minimum education:

  • A Bachelor’s degree in a relevant scientific area is required.
  • Ph.D. preferred.


Minimum Experience:

  • Two (2) years of relevant, post-degree work experience is required for a Bachelor's degree.
  • No experience is required with a Master's degree.
  • Post-degree experience preferred.
  • Direct experience with expression, purification, and functional characterization of GPCRs and their transducers (G-proteins, arrestins, GPCR kinases, etc.) is highly preferred.
  • Prior experience in single-molecule fluorescence analyses and/or GPCR biology is highly preferred.


Selected Publications:


Have More in Memphis

Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.”




In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Senior Researcher in Structural Biology – Scott Blanchard Lab.


Explore our exceptional benefits!



Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.


Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.


St. Jude is an Equal Opportunity Employer


No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.


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