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Scientist (GPCR) - Protein Technologies Center

St. Jude Children's Research Hospital (St. Jude)
Memphis, Tennessee
Commensurate with experience
Closing date
11 Oct 2024

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Health Science
Job Type
Employment - Hours
Full time
We are seeking a Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project.



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The world’s brightest researchers and most compassionate caregivers come to St. Jude to experience world-class resources and unmatched support to do amazing work. Here you can be part of a collaborative culture that will inspire you every day to be your best. Join us and you’ll quickly learn why St. Jude is consistently ranked as one of The Commercial Appeal’s Top Workplaces in the greater Memphis area.



The Protein Technologies Center (PTC) in the Department of Structural Biology is seeking a highly motivated Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the molecular determinants and fidelity of GPCR signaling in health and disease. As part of the collaborative grant, the candidate will work closely with several partnering labs (Scott Blanchard, Madan Babu, Robert Lefkowitz, Alice Ting, Jonathan Javitch, and Georgios Skiniotis).


Successful candidates should have demonstrated competencies in the following areas:

  • Cloning, expression, purification, and biochemically characterizing membrane proteins from mammalian and/or insect cell systems.
  • Prior experience with membrane protein or GPCR structural studies or functional assays.
  • A significant contribution towards peer-reviewed research articles in the related scientific subject(s).
  • Excellent record-keeping, communication, and presentation skills and ability to prepare high-quality manuscripts of findings for publication.



  • Design constructs, clone, express, and purify GPCRs, G-proteins, arrestins, and other signaling proteins for structural, functional, and biophysical experiments to investigate structure-dynamics-function relationships.
  • Structure determination using either CryoEM or x-ray methods.
  • Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
  • Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
  • Train and mentor graduate students, post-docs, and visiting scientists.
  •  Instruct other staff in basic laboratory techniques and procedures.


Minimum Education and/or Training:

  • Bachelor's degree in relevant scientific area is required.
  • Ph.D. in molecular biology, biochemistry, protein engineering, or any related discipline preferred. 


Minimum Experience:

  • Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree.
  • Five (5) years of relevant post-degree work experience is required with a Master's degree.
  • Three (3) years of relevant post-degree work experience is required with a PhD.


Have More in Memphis:

Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.”





In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist (GPCR) - Protein Technologies Center.


Explore our exceptional benefits!



Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.


Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.


St. Jude is an Equal Opportunity Employer


No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

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