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Postdoctoral Position in Structural Biology (M/W)

Employer
French National Institute for Health Research (INSERM)
Location
Bordeaux (Ville), Gironde (FR)
Salary
Upon experience and according to INSERM salary standards
Closing date
31 Mar 2024

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Discipline
Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

Job Details

Mission – We are looking for a highly motivated post-doc with expertise in structural biology of membrane proteins, molecular biology and biochemistry to unravel the molecular mechanisms of a receptor kinase associated with human health and diseases.

The project involves a close collaboration between the group of Dr Pierre Maisonneuve at the University of Bordeaux (UMR 5248 CNRS, IECB, France), which investigate the structural mechanisms of protein kinases in human signaling by using cryo-EM and X-Ray crystallography (1-3) and the group of Dr. Xavier Guillory at the Université de Rennes (Inserm U1242, Rennes, France), which aims at deciphering and targeting the molecular mechanisms of activation of a receptor kinase (4,5). The selected candidate will be based in Dr. Maisonneuve's lab in Bordeaux, France. The position is fully funded as part of the INSPIRE1 research program funded by the French National Research Agency (ANR).

Main activities

• Molecular biology (design and conception of plasmids for protein expression).

• Protein expression in procaryotic (bacteria) and eukaryotic (insect and human) cells.

• Purification of membrane proteins and incorporation in nanodiscs.

• Structural characterization of membrane proteins by single particle cryo-EM.

• Functional and biophysical characterization in vitro of enzymatic activities (kinase & RNase), substrate specificity (RT-qPCR), protein-protein interactions (ITC, fluorescent spectroscopy, SPR, BLI and others).

Required abilities

• Expertise in protein biochemistry (ideally in membrane proteins)

• Single-particle electron microscopy (cryo-EM)

• Protein expression in human cells.

• Use of detergents, lipids or amphipols. Previous experience on nanodiscs represents a plus.

• Ability to work independently and as a team member.

• Good communication & organizational skills

Environment

The candidate will join an exciting and multidisciplinary scientific environment with on-site access to cutting-edge facilities in cryo-EM, X-Ray crystallography, NMR, Biochemistry, Biophysics, molecular biology and cell biology.  The Université of Bordeaux is a Top French university. It offers a dynamic and lively international campus with an ideal location just 2 hours from Paris, the sea and the mountains. 

Position

Application deadline: 31st of March, proposed start date: May - July 2024

• Required experience: 2 - 8 years after PhD.

• Fixed term contract, 18 months, but the candidate is encouraged to apply for additional postdoctoral funding.

• Salary: Upon experience and according to INSERM salary standards.

Please send CV, cover letter and at least two contacts likely to provide recommendation to:

Dr. Xavier Guillory - xavier.guillory@univ-rennes.fr

Dr. Pierre Maisonneuve - p.maisonneuve@iecb.u-bordeaux.fr

1. Maisonneuve, P., Sahmi, M. et al.  Nat Struct Mol Biol (2024). 2. Posternak, G., Tang, X., Maisonneuve, P. et al. Nat Chem Biol 16, 1170–1178 (2020). 3. Lavoie, H., Sahmi, M., Maisonneuve, P. et al. Nature 554, 549–553 (2018). 4. Pelizzari-Raymundo, D., […], Guillory, X., iScience, 26, 106687 (2023). 5. Langlais, T., […], Guillory, X., Biochem. J., 478, 2953-2975 (2020)

Company

Founded in 1964, Inserm is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. Inserm brings together 15,000 researchers, engineers, technicians and administrative staff, all with one shared objective: improve health by advancing knowledge about living organisms and diseases, developing innovative treatment modalities and conducting research on public health.

Company info
Website
Telephone
+33144236277
Location
101 Rue de Tolbiac
Paris
Paris
75013
FR

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