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Post-Doctoral Research Fellow - Ring Lab

Employer
Fred Hutchinson Cancer Center
Location
Seattle, Washington State
Salary
$67,728 to $100,000
Closing date
12 Apr 2024

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Discipline
Health Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Charity/NGO

Job Details

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

 


With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

 


At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

 


The Ring Lab of Synthetic and Systems Immunopharmacology is located within the Translational Science and Therapeutics Division and is a member of the Immunotherapy Integrated Research Center (IIRC). Their primary focus is on developing unique and first-in-class therapeutic drugs for cancer immunotherapy using cutting-edge protein engineering with directed evolution. The lab has developed therapeutics that are currently in clinical trials, such as ST-067 (a "decoy-resistant" IL-18), MDNA-11 (CD122-biased IL-2), and ALX-148/evorpacept (an ultra-high affinity SΙRPα decoy). Moreover, the Ring Lab is actively working on developing platforms for identifying new targets in cancer immunotherapy. These technologies include the REAP platform for discovering autoantibodies in patient samples, and high-throughput techniques in synthetic antibody engineering and proteogenomics to pinpoint new tumor antigens.

 

 

 

Please include a cover letter with your application detailing your interest in this position.

 

Responsibilities The Ring Lab is recruiting a Post-Doctoral Research Fellow with expertise in immunology, systems/computational biology, and/or protein engineering. This position will involve research projects that investigate the relationship between patient autoantibodies and health and disease outcomes. At the core of these programs is the REAP autoantibody profiling technology, which provides unprecedented levels of detail about the "autoantibody reactome" present in patient blood and tissue samples. Researchers will perform the very first "autoantibody-wide association studies" to pinpoint how specific autoantibody reactivities impact disease biology, analogous to but independent from the effect of genetic variation. This entirely new research program is poised to identify novel therapeutic targets for a range of indications including cancer, autoimmune disease, inflammatory conditions such as IBD, infectious disease, and neurodegeneration.

 

 

 

The ideal candidate will be a highly-curious, motivated, independent, and collaborative research scientist keen to explore new areas of biology and therapeutic development. They will work closely with Dr. Ring, lab manager Alison Almeda, external collaborators, and other members of the Ring laboratory to execute highly-multidisciplinary studies. Furthermore, they will have the opportunity and responsibility to contribute to the preparation of research reports and scientific manuscripts, as well as present at scientific conferences and symposiums. The Ring lab welcomes candidates with a diverse range of career aspirations and has a track-record of supporting trainees to pursue careers in academia, biotech/pharma, life-science investing, and consulting.

 

Qualifications

  • MD or PhD in a related field
  • Experience in one or more of the following areas:
    • Immunology
    • Systems biology/bioinformatics
    • Single cell transcriptomics/proteogenomics
    • Protein engineering/directed evolution with yeast, phage, or mRNA/ribosome display technology
  • Excellent verbal and written communication skills
  • A team player with strong aptitude for collaboration

 


The annual base salary range for this position is from $67,728 to $100,000 and pay offered will be based on experience and qualifications.

 

 

 

 

This position may be eligible for relocation assistance. 

 


Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).

 

Company

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit of, and passion for, health knowledge and hope to their work and the world. Together, our researchers are discovering new ways to detect cancers earlier, when cure rates are highest; developing effective treatments with fewer side effects; and learning how to prevent cancers from growing in the first place.

Our groundbreaking discoveries began in the 1970s with Dr. E. Donnall Thomas’s pioneering work in bone marrow transplantation, which led to him receiving the 1990 Nobel Prize in physiology or medicine. Since then, Hutch researchers have made a number of breakthroughs, including developing immunotherapies that use the immune system to defeat cancer and advancing the understanding of human biology. 

Admittedly, the eradication of cancer and other life-threatening diseases is an ambitious goal, one that demands tenacity, scientific excellence, collaboration and breakthrough creativity. To accomplish this, Fred Hutch attracts some of the world's greatest minds.

Our roster of internationally acclaimed scientists includes a MacArthur fellow, members of the National Academy of Sciences, members of the Institute of Medicine, members of the American Academy of Arts and Sciences, members of the American Association for the Advancement of Science and current and former Howard Hughes Medical Institute investigators.

Fred Hutch understands that disease research means more than searching for new treatments. We are home to the country's largest and oldest cancer prevention program, which has made key contributions to understanding how diet, exercise and other factors reduce the risk of acquiring the disease.

To accelerate our progress, we are part of the Fred Hutch / University of Washington Cancer Consortium. This research and clinical collaboration between the Hutch, the University of Washington, Seattle Children’s and Seattle Cancer Care Alliance enables our researchers to leverage each institution’s strengths and develop premier research programs across many types of disease. The Consortium is among 49 National Cancer Institute-designated comprehensive cancer centers nationwide.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Company info
Location
Seattle
WA
98109
United States

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