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4-year Group leader position

Hellenic Pasteur Institute
Hellenic Pasteur Institute, Greece (GR)
Salaries for the whole team can not exceed the 50% of funding yearly (100.000€/year)
Closing date
6 Feb 2024

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Biomedicine, Chemistry, Clinical, Health Science, Life Science
Job Type
Principal Investigator, Researcher
Employment - Hours
Full time
Fixed term

Job Details

4-year Research Group
Call for nomination at the Hellenic Pasteur Institute

A 4-year Group leaders’ position is open at the Hellenic Pasteur Institute on one (1) of the following topics:

 A. Host- Pathogen Interactions.

Pathogens’ direct or indirect interaction with the host cell and its effect thereafter is a  continuously emerging field. Pathogens manipulate mechanisms at the molecular, biochemical, and biophysical level, evoking a cellular response that facilitates pathogens’ survival and propagation. Studying these mechanisms not only provides insight into cellular mechanisms but also in the process providing novel targets for drugs and diagnostics. Pathogens’ evolving complexity helps to develop resistance against drugs by developing newer pathways, necessitating research for newer drug targets. Pathogens can also modulate
host cellular functions and induce an uncontrolled proliferation of cells leading to cancer.

Indicative potential topics may include but are not limited to the following:

• Host response to infection and co-infection; • Cellular effects on the host in response to toxins or other metabolites secreted by the pathogen; • Mechanisms of intracellular survival; • Molecular and biochemical response during host-pathogen interaction; • Regulation of cellular proliferation; • Advances and challenges in drug design, immune responses and vaccine development, and therapeutics; • Advances and challenges in designing and developing diagnostics and sensors.

B. Antimicrobial drug resistance

 Antimicrobial resistance within populations of different infectious agents is a worldwide publichealth threat. Already the available treatment options for common infections in some settings are becoming ineffective. There are now reports of bacterial resistance to all antibiotic classes used in either human or veterinary medicine, and in several cases, of an association between antibiotic use and the development of clinical resistance. To counter this emergent problem, the World Health Organization has appealed for urgent and concerted action by governments, health professionals, industry, civil society and patients to slow down the spread of drug resistance, limit its impact today and preserve medical advances for future generations in different ecosystems.

Indicative topics may include but are not limited to the following:

Epidemiology of resistance in animal and zoonotic pathogens • Mobile elements containing resistance genes •The omics of antimicrobial resistance • Emerging antimicrobial resistance mechanisms
• Control of resistant infections • Biofilms

The International Call 2023 for applications for a 4-year Research Group will support one (1) new G4 award holder with a group-leader career development opportunity of up to 400,000€. The successful applicant should propose an innovative research project on one of the above topics HPI is a member of the Pasteur Network, with specific missions within the scope of the study and control of infectious diseases. The G4 award holder will benefit of the HPI’s platforms e.g. Light Microscopy Unit, FACS Analysis Unit, Department of Animal Models for Biomedical Research and Transgenic Technology.The G4 leader will have the possibility to interact with experienced researchers of the HPI. Cooperation with other scientific partners in Greece will be encouraged.

Who can apply for a  G4 PI position?

 The G4 applicant should ideally be an early to mid-career post-doctoral scientist, wishing to establish a research group as an independent researcher at the HPI. The G4 team, as employees of the HPI, must adhere to its rules and regulations.An enabling environment should motivate the G4 award holder to pursue his/her career at the HPI with the prospect of obtaining a permanent position at the end of the award tenure. As the HPI is member of the Pasteur Network, it is expected that the G4 PI will express a willingness to participate in the development of this network by strengthening research through collaboration and training across the Pasteur Network. As for any research group, the G4 award holder will be encouraged to develop and strengthen his/her capacity to manage a team and to welcome and supervise Masters and PhD students,  as well as interns. A G4 PI can also hire postdoctoral researchers. During his G4 leader years the successful candidate will have to apply to international grants to secure the financial sustainability of his research group.The HPI should support the G4 PI to become an independent researcher and a future scientificleader in his field. Mentorship for the candidate will be put in place and a training on management will be offered (by the host institution). Successful candidates may  be offered a permanent position at the end of the G4, as provided by the Greek legislation for the recruitment of researchers.

The partnership with Institut Pasteur

 Institut Pasteur will support the career development of the G4 PI through four (4) annual payments of up to €100,000, payable at the beginning of each financial year. This fellowship can finance salaries up to 50% of its total annual amount.All scientific and ethical standards and requirements, in accordance with the statutes of the HPI and Institut Pasteur, need to be respected as stipulated in the agreement relating to the G4. This agreement will also define the start date of the G4, which will be agreed with each successful applicant. The period of tenure of a G4 award is 4 years.


Deadline for online submission : 29th February 2024, 12.00 CET

Eligibility and Selection Criteria 
Any scientist holding a PhD in Host-Pathogen Interractions or Antimicrobial Resistance, or
related field and having 5 to 10 years of post-doctoral research experience can apply for G4
The call is open to researchers of any nationality.
The candidate cannot already have a permanent position at the HPI.
To have already financed projects is an asset
Selection criteria
The candidate will be evaluated against the following criteria:
• Quality of his/her research
Did the research projects carried out by the candidate result in measurable outputs or
outcomes in public health or in fundamental knowledge on the subject of interest
(peer reviewed articles, patents, etc.)?

Capacity to finance his/her projects
Has the candidate shown real ability in securing grants from national or international
funding agencies?

• Collaborations and any plans to develop strategic local and regional partnerships
Has the candidate demonstrated the ability to initiate, maintain, and develop
research collaborations?

• Supervision and training
What management and training experiences does the candidate have?
Does the candidate demonstrate their willingness to be involved in the training of local
young scientists?

• Peer recognition
Has the candidate’s work been recognised by the scientific community through awards,

Has the candidate been invited to participate in international scientific events?

The proposed research project will be evaluated not only on its quality, originality, and feasability but also on the added values it will bring to the host institute and its contribution to the regional/global health priorities. It is expected that the candidate will bring an experience working on host pathogen interactions or antimicrobial resistance
Thus, the right match between the candidate and the host institute will be pivotal, for as well as the motivation of the candidate to participate to the scientific strenghthning of the Network.
The proposed research project will be evaluated not only on its quality, originality, and feasability but also on the added values it will bring to the host institute and its contribution to the regional/global health priorities. It is expected that the candidate will bring an experience working on host pathogen interactions or antimicrobial resistance.
Thus, the right match between the candidate and the host institute will be pivotal, for as well as the motivation of the candidate to participate to the scientific strenghthning of the Network.

Applications must be written in English and submitted online. Incomplete or paper-based applications will not be considered.
Deadline for online submission: 29th February 2024, 12.00 CET
When deemed necessary, the Institut Pasteur reserves the right to ask candidates for additional information in order to evaluate their application.
Candidates must not submit information in their application that is confidential and/or protected by the intellectual property rights of third parties, and may contravene any rights of third parties.

The Department of International Affairs of Institut Pasteur oversees the G4 selection process.
Each application will be reviewed by two (2) scientists from our experts panel. The final
decision will be made following the panel meeting, to which the Hellenic Pasteur Institute
director or its representative will be invited, and confirmed by the executive management.
Candidates will be notified in due course.
The Department of International Affairs of Institut Pasteur is responsible of the follow-up
process of the G4. As part of the evaluation, each year, the G4 PI should provide a complete
progress report regarding the scientific activities, incuding details on annual expenditures.

Each G4 PI will be paired with a suitable mentor, offering advice and guidance for all aspects
relating to G4 management and career development. The mentor will be identified from a
pool of experienced scientists who already have experience in leading a research group within
the pasteur Network. The G4 PI or the host institute direction can also suggest mentor to the
Pasteur Network fondation.
Questions related to this Call must be directed to:
Hellenic Pasteur Institute
G4 position:
Chair-person of Scientific Council: Sissy Kolyva:
Institut Pasteur
G4 Programme: Marianne Lucas-Hourani



The Hellenic Pasteur Institute (HPI) is a non-profit research Institute dedicated to the prevention, diagnosis and treatment of infectious, autoimmune, and neurodegenerative diseases through innovative research and Public Health services.  The HPI is member of the Pasteur Network. maintains fruitful scientific and educational synergisms with the Pasteur Institute in Paris, other Research Institutes and the Academia worldwide.


A strategic goal of the HPI is to address key global health challenges using cutting-edge and high-throughput technologies in emerging scientific and technological fields of National and EU priorities. In accordance with its strategic plan to support its priorities in basic and translational research and in public health, eight new researchers integrated in HPI, bringing new approaches and further develop and expand both existing and novel research and technological activities. HPI has also invested towards the development of state-of-the-art infrastructures and related scientific approaches, including: Next Generation Sequencing and novel Bioinformatics analysis tools applied both in research and diagnosis; reprogrammed stem cells and human induced Pluripotent Stem cells (hiPS) for disease modeling; live cell and whole animal imaging for monitoring dynamic cellular interactions and structural biology for new drug development. At the same time expansion and renovation of the existing Vaccine Unit and BSL3 Diagnostic Unit for small scale production of vaccines and biological products and safe handling of highly pathogenic agents respectively, are in progress. Additionally, HPI has dedicated a significant part of research effort for the investigation of antibiotic resistance and the development of immunotherapeutic products, both of which constitute major societal health challenges and major national and EU research priorities for the forthcoming period.


By investing in the capacity building and in innovative cutting-edge technologies, the HPI increased its capacity for obtaining grants from National and International funding bodies as well as contract research.


Future objectives include the establishment of new technological platforms and the attraction of funds for increasing the Institute’s building and lab space capacity and for expanding to high throughput –omics approaches. 


HPI aims to respond to emerging and re-emerging diseases challenges, foster future scientific goals in concert with national and international research priorities. HPI encourages the research groups to work on well-defined scientific questions, to foster a dynamic atmosphere and optimize efficacy and flexibility.


Importantly, within the next four years a new centralized, integrated Pathogens Research Center (HPI-PRC) of HPI is expected to be completed within the actual premises, containing increased-biosafety (BSL3+) laboratories equipped with robotic systems to enable culture isolation and maintain in vitro experimental models of infectious diseases, assuring bio-risk standards.




eases through innovative research and Public Health services.  The HPI is member of the Pasteur Network since its foundation. 


Company info
Hellenic Pasteur Institute
Vas. Sofias 127

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