Three-year full time Postdoc Research Fellowship in cancer immunology is available at the Department of Pathology, Institute of Clinical Medicine, The Faculty of Medicine, University of Oslo.
More about the position:
The positions is available from February 2024. The position will be located in the laboratory of Professor Jahnsen at Oslo University Hospital – Rikshospitalet (website: jahnsenlab.org). The aim of the project is to understand the role of the immune tumour environment in colorectal cancer with and without metastasis.
The Jahnsen team has a very strong record in human mucosal immunology research and has over the last few years built very strong competence in bioinformatics for single cell multiomics analysis. In this project we will collaborate with internationally and nationally leading research groups within cancer biology and cancer genetics, bioinformatics and imaging, oncology, and gastrointestinal surgery. We will apply an integrated approach combining high throughput single-cell technologies with advanced imaging techniques including spatial transcriptomics. We have access to a unique well characterized clinical biopsy material from several thousand colorectal patients. We will also perform functional in vitro studies and culture complex organoids to study tumour-immune cell interactions in a near in vivo situation.
The successful candidate will work closely with bioinformaticians in the group and the project will use
advanced single cell technologies combining scRNA-seq/TCR-seq/BCR-seq with epigenomics (scATAC-seq
etc) as well as state-of-the-art imaging techniques.
The candidate will:
1. Establish methods to integrate multiomics with spatial transcriptomics to analyse the immune tumour microenvironment in time and space at the single cell level
2. Establish new methods for single cell analysis using machine learning/deep learning
3. Perform analysis of single cell and bulk RNAseq data
4. Perform image analysis of multiplex immunochemistry
The project will be supervised by Prof. Jahnsen, Prof. Bækkevold and Dr. Domanska (bioinformatics) – all working in the Jahnsen group. The lab consists of 15 people all working on different aspect of mucosal immunology. The lab has extensive collaborations with international groups in bioinformatics, immunology and cancer biology
The ideal candidate should meet the following criteria:
- Applicants must hold a PhD degree in computational biology, bioinformatics, biology, immunology, or a related field.
- Experience in bioinformatics including programming languages such as R and Python.
- Experience with computational genomics data analysis
- Experience in machine learning/deep learning techniques
The candidate will work in a very ambitious interdisciplinary setting, which will require high flexibility. Fluent oral and written communication skills in English. The Faculty of Medicine has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.
An exciting research environment with opportunities for academic development.
How to apply
The application must include:
Application letter describing the applicant’s qualifications and motivation for the position
CV (summarizing education, positions, and academic work - scientific publications)
A complete list of publications
Copies of educational certificates and transcript of records
List of publications and academic work that the applicant wishes to be considered by the evaluation committee
Letters of recommendation or names and contact details of 2-3 references (name, relation to candidate, email and telephone number)
The application with attachments must be delivered in our electronic recruiting system, please follow the links “apply for position”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
Applicants, who are invited for an interview, are asked to provide educational certificates, diploma or transcript of records.