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Two postoctoral positions in TFs and cancer biology at the University of Helsinki

Employer
Helsinki University
Location
Helsinki, Uusimaa (FI)
Salary
3600-4000 €/month (OV5 + performance percentage) according to the appointee’s qualifications
Closing date
28 Jan 2024

View more

Discipline
Biomedicine
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

The Laboratory of Prof. Jussi Taipale (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology) as part of the Applied Tumour Genetic Program in the Faculty of Medicine at the University of Helsinki invites applications for two postdoctoral researchers.

 

The research group is part of the Academy of Finland's Centre of Excellence in Tumour Genetics Research and focuses on the study of transcriptional control of cell growth using functional genomics and systems biology. Currently, the lines of research include high-throughput determination of binding sites and binding specificities of human transcription factors that control cell growth during steady state and in cancer.

Applicants with a doctoral degree and a strong background in molecular biology and knowledge/interest in bioinformatics who wish to work in an inter-disciplinary, highly dynamic and international environment are particularly encouraged to apply. Applicants are expected to work independently and have good command of English. The appointment will be initially for two years with the possibility to be extended. A trial period of 6 months will be applied. 

The University of Helsinki welcomes applicants from a variety of genders, linguistic and cultural backgrounds.

The deadline for applications is the 28th January 2024 at 23:59 EET.

Further information


Selected publications from Taipale lab:

1. Pihlajamaa P, et al. A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites. Nat Biotechnol. 2023 Feb;41(2):197-203.

2. Sahu et al. Sequence determinants of human gene regulatory elements. Nature Genetics, 2022, April 283–294.

3. Yan J, et al. Systematic analysis of binding of transcription factors to noncoding variants. Nature. 2021 Mar;591(7848):147-151.

4. Dodonova SO, et al. Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature. 2020 Apr;580(7805):669-672.

5. Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.

6. Haapaniemi E, et al. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat Med. 2018 Jul;24(7):927-930.

 

About us

The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare. The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally. Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.

 

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