The Faltas Lab at Weill Cornell Medicine in New York City is seeking motivated postdoctoral fellows and research associates to join our dynamic team. The Faltas lab focuses on the mechanisms that induce genome instability in urothelial cancer, the resulting intra-tumor heterogeneity, and the evolution of drug resistance and metastasis. We use a multidisciplinary approach by integrating experimental models, such as cell lines, patient-derived organoids, and animal models, with cutting-edge computational biology techniques. Research from the Faltas Lab has been published in Nature, Nature Genetics, Nature Communications, Cancer Research, and other high-impact journals. The lab is supported by grants from the NCI (R37 MERIT award funding for the next 7 years), the Department of Defense, the Starr Cancer Consortium, and other sources.
Based in New York City, our team thrives in a vibrant, culturally rich environment, offering numerous networking and academic opportunities in this global hub of innovation. We offer competitive salaries (higher than the postdoctoral NIH stipend). Weill Cornell Medicine provides comprehensive benefits, including health, dental, and vision insurance coverage and subsidized housing. Mentoring is a priority for Dr. Faltas, and the laboratory offers a rich and diverse scientific environment for professional development. Experience at the Faltas Lab fosters substantial career growth, paving the way for advanced research roles.
Ongoing and future projects in the lab include:
- Investigating the role of APOBEC3 cytidine deaminase mutagenic enzymes in driving intra-tumor heterogeneity and the biological function of APOBEC3-induced mutations and RNA-editing.
- Investigating the role of structural variants, such as extrachromosomal DNA, in the evolution of therapy resistance.
- Translational projects leveraging our findings for personalized therapy and drug development for patients with urothelial and other cancers.
- Ph.D. in molecular biology, cell biology, biochemistry, pharmacology, or related fields with a strong background in cancer biology. Excellent skills in basic molecular biology and biochemical techniques, including cloning, SDS-PAGE western blotting, qPCR, functional assays, and mammalian cell culture.
- Experience in mouse handling and experiments, such as tumor xenograft models and tail vein injections, is a plus.
- Familiarity with basic R or Python is a plus but not required.
- Excellent communication, organizational, and problem-solving skills. Track record of productivity (publications) from Ph.D. is a plus.
Interested applicants are encouraged to send their CV, a statement of research interests, copies of previous publications, and names and contact information of three references to Dr. Bishoy M. Faltas, before the application deadline.