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Post POSTDOCTORAL POSITION -- DEPARTMENT OF UROLOGY – BOSTON CHILDREN'S HOSPITAL AND HARVARD Fellow

Employer
Boston Children's Hospital (BCH)
Location
Boston, Massachusetts
Salary
Depending on PGY Level
Closing date
6 Jan 2024

View more

Discipline
Health Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Hospital

 

 A postdoctoral position is open in the Urology Research Program at Boston Children's Hospital and Harvard Medical School working with the Lee and Froehlich laboratories, and in collaboration with the Adam laboratory. The focus of the position will be on investigating the urinary proteome to identify novel and clinically relevant markers of renal damage, urinary tract infection, and bladder dysfunction, and to apply systems biology approaches to integrate biomarker analyses with molecular mechanisms. In addition to a large human biobank, animal models of urologic disease will be employed to test novel treatment modalities in collaboration with the Adam laboratory. Candidates will be responsible for various aspects of proteomic and biochemical experiments from sample preparation to MS method optimization and data analysis. These projects will require experience in mass spectrometry, protein modifications and bioinformatics, including a strong knowledge of LC-ESI-MS/MS and HPLC operation, as well as experience in the integration of large ‘omic datasets. Experience with cell biology is also preferred, but not necessary. Boston Children’s Hospital is the pediatric teaching hospital for Harvard Medical School and offers a rich environment for translational research. Individuals with appropriate experience from underrepresented groups are strongly encouraged to apply. 

Interested candidates should send their CV and a one page summary of research background and goals to: 

Nicholas Fisher 

Urological Diseases Research Center 

Enders Research Building, Rm 1043 

Boston Children’s Hospital 

Email: nicholas.fisher@childrens.harvard.edu 

Tel: 617 919-2643 

Selected Papers of interest: 

Vaezzadeh AR, Briscoe AC, Steen H, Lee RS. One-step sample concentration, purification, and albumin depletion method for urinary proteomics. J Proteome Res. 2010;9(11):6082-9 

Zhou H, Briscoe AC, Froehlich JW, Lee RS. PNGase F Catalyzed De-N-glycosylation in a Domestic Microwave. Anal Biochem. 2012 Aug 1;427(1):33-5. 

Froehlich JW, Dodds ED, Wilhelm M, Serang O, Steen JA, Lee RS. A Classifier Based on Accurate Mass Measurements to Aid Large-scale, Unbiased Glycoproteomics. Mol Cell Proteomics. 2013 Apr;12(4):1017-25. 

Zhou H, Froehlich JW, Briscoe AC, Lee RS. The GlycoFilter: a simple and comprehensive sample preparation platform for proteomics, N-glycomics and glycosylation site assignment. Mol Cell Proteomics. 2013;12(10):2981-91. 

Zhou H, Warren PG, Froehlich JW, Lee RS. Dual modifications strategy to quantify neutral and sialylated N-glycans simultaneously by MALDI-MS. Anal Chem. 2014;86(13):6277-84. 

Zhou H, Morley S, Kostel S, Freeman MR, Joshi V, Brewster D, Lee RS. Universal solid-phase reversible sample-prep for concurrent proteome and N-glycome characterization. J Proteome Res. 2016 Mar 4;15(3):891-9. 

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