Understanding T and B Cell Responses Using Systems Immunology
A fully funded postdoctoral fellow position is available in the laboratory of Ramin Sedaghat Herati, MD. We study human immune responses to stimuli by focusing on the interactions of T follicular helper (Tfh) CD4 cells and B cells and the effects on the antibody response. Our long-term goal is to understand CD4+ T and B cell responses in different immunological contexts, including in the settings of infection, vaccines, cancer immunotherapy, and xenotransplantation. We seek to understand mechanisms of immune biology based on our observational and interventional clinical trials, which were specifically designed with immunological questions in mind.
We use a combination of high-content methods to interrogate the immune response. These include high-parameter spectral flow cytometry, combined CITEseq and ATACseq, and CODEX multiplex immunofluorescence imaging, which are brought together with custom bioinformatics pipelines for analysis. Our lab is part of NYU Langone’s Vaccine Center, as well as the Immunology Research Program, Perlmutter Cancer Center, and Translational Immunology Center.
Example projects include the following:
- understanding the development of the de novo T and B cell response to hepatitis B vaccination using systems immunology approaches de novo and recall germinal center formation in human lymphoid tissue long-term consequences of high-grade inflammation during memory T and B cell formation
We work with the postdoctoral fellow to identify relevant training and help to continue to scientific development to progress towards independence. Learn more about our lab at teamtfh.org.
The salary range is $70,000 to $75,000.
Competitive candidates will have a doctoral degree and a background in immunology, including substantial experience with flow cytometry, scRNAseq, and/or data science. Passion, enthusiasm, and great communication skills are essential.
To apply, please send your CV, a cover letter with a summary of your research experience, and contact information for references to Dr. Herati at Ramin.Herati@NYULangone.org.