We are looking for PhD candidates to join the TACsy (Training Alliance for Computational Systems Chemistry) Marie-Sklodowska-Curie Joint Doctoral Network. This network consists of fifteen (15) highly interlinked PhD projects, of which this particular call is for project DC 12: Pathway Design for Chemical Upgrading and Co-Factor Recycling with Cell Extracts.
The application deadline is 23 October 2023.
The anticipated start date is 1 January 2024, but flexibility in both directions is possible.
This position lies at the interface of chemistry and biological/chemical engineering and aims to develop new computational techniques for design of multi-enzyme cascades (MECs) for applications. Upgrading of chemicals such as caffeine to more valuable products can be difficult to achieve using conventional synthetic methods. However, strategies are emerging involving MECs, and the exploitation of enzymes found in cell extracts has proved effective under certain conditions. Computational methods allow us to explore the diversity of the MEC design space in-silico prior to wet-lab implementation and will thus hugely speed up the development process of productive MECs. The project will involve the investigation of potential pathways using computational techniques at the University of Vienna and a nine month secondment at the University of Sheffield to develop microfluidics methods for process optimization with encapsulated cell extracts. You will also undergo a short secondment to the company Fluigent for training in microfluidics.
We are seeking a PhD candidate that has or is expected to have a Master's degree in chemical/biochemical engineering, computer science, chemistry or related discipline at the time of recruitment. Some knowledge of enzyme kinetics, systems chemistry/biology or mathematical biology would be beneficial. Willingness to travel and work as part of an interdisciplinary team is essential.
See details about the network as a whole, its scientific content, and the application and selection process here.
Please note that there are two limitations to apply for this programme, as specified in the MSCA regulations. Applicants must:
- Not be in possession of a PhD degree at the date of recruitment.
- Meet the Marie-Curie mobility rule (see pages 81-82 here). In TACsy, this means the applicants are not eligible for a specific position if it is true for both host institutions of the position that the applicant for more than 12 of the last 36 months has resided or performed a main activity (work, studies, etc.) in the country of that host institution. The host institutions relevant to this rule are for the present call located in (DC 1: Denmark and Germany), (DC 3: Austria and Germany), (DC 6: Austria and Germany), (DC 12: Austria and Denmark), (DC 13: Austria and Denmark).
These positions are subject to the entry into force of grant agreement no 101072930 by and between the European Research Executive Agency and University of Southern Denmark and thereby funded by the European Union's Horizon Europe Research and Innovation Programme.
Please see the full call, including how to apply, on www.sdu.dk.