Area of research:
PHD ThesisStarting date:
The Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association is an international biomedical research center dedicated to understanding the molecular mechanisms of health and disease with the goal to devise new diagnostics and medicines. The MDC is a member of the Helmholtz Association, Germany's largest scientific organization, and offers an engaging research environment with cutting-edge research infrastructure. Currently, ~1250 employees and ~500 guest scientists work at the Berlin-Buch and Berlin-Mitte campuses. Our diverse workforce is a core strength that inspires creativity and innovation at the MDC.
The MDC is committed to improving human health through transformative biomedical research. Our goal is to pioneer discoveries for preventing, treating, and ultimately curing disease.
The Mittnenzweig lab develops new computational approaches for single-cell multiome, genomic and spatial transcriptomics data. We are interested in building quantitative models of the regulatory code and the intercellular signals that drive cell fate decisions in development and disease and how this code has evolved during animal evolution. In collaboration with experimental groups, we are working on vertebrate embryonic development and synthetic organoid models that reconstitute developmental and disease processes.
Our group is looking for a highly motivated PhD student (m/f/d) to develop new machine learning methods for the analysis of spatiotemporal single-cell data in the context of mammalian embryonic development, and to compare it with the embryonic development in other vertebrate model species.
- You will develop new algorithms to infer cellular differentiation trajectories in the developing embryo from time-resolved single-cell RNA, spatial transcriptomics and lineage tracing data
- You will use machine learning methods to combine spatial transcriptomics data with other data modalities such as single-cell transcriptome or advanced microscopy data
- You will compare mouse embryonic development with a variety of other species (e.g. human, fish, bird) and synthetic embryo models
- You will analyse and compare synthetic organoid development with in vivo embryonic development
- You will work closely with experimental collaborators
- You will be an active member in a highly interdisciplinary team, that involves data scientists and computational and experimental biologists
- MSc degree in the computational or natural sciences
- Strong computational or quantitative focus (computational biology, bioinformatics, mathematics or a related field)
- Strong programming skills (Python, R) are essential; experience in building efficient and reusable software would be a plus
- Excellent communication skills facilitating frequent exchange with group members and scientific collaborators
- Solid statistical knowledge and experience with state-of-the-art machine learning methods
- Ability to work independently and to undertake challenging analysis tasks
- international working environment with communication in English and German
- interesting career opportunities and a range of opportunities for further qualification and training
- Compatibility of family and career certified by the workandfamily audit (“berufundfamilie audit”)
- Support for "New Berliners" through the MDC Welcome & Family Office
- On-campus health and fitness center
- Stimulating and international research environment with excellent science
- Opportunity to work on cutting-edge biomedical data
- Ability to become an expert in single-cell genomics and machine learning approaches to biomedical data
You also benefit from:
- A remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
- Flexible working hours and childcare support
- Subsidy for the job ticket
- Additional health benefits such as flu vaccination, eye test, ergonomics advice at the workplace
- The possibility of mobile working
Team: Mittnenzweig Lab
Publication period: 21.09.2023 - 22.10.2023
Desired starting date: 01.02.2024
Job location: MDC Berlin-Mitte
Hannoversche Str. 28
Employment period: Fixed Term
Scope of employment: PhD
Salary: Remuneration will be according to the TVöD Bund, depending on the personal requirements, up to the fee group 13
Application: Please use our online portal and submit your application including a cover letter, CV (without photo, age and information about your family status) and other relevant attachments.
If you have a foreign degree, please submit proof of the recognition of your Master's degree in Germany with your application. The proof can be determined via the anabin database (https://anabin.kmk.org/anabin.html) and can be submitted as a PDF attachment to the application.
For information on fair mobility, click here: www.fair-labour-mobility.eu
Parity and equal status: All qualified applicants will receive consideration for employment without regard to ethnicity, color, religion, sex, national origin, disability, age, gender identity or sexual orientation. We look forward to receiving applications from open-minded people who enjoy working in diverse teams. Applications from severely disabled persons will be given special consideration.
Further links: www.mdc-berlin.de/mittnenzweig
Bei Fragen zur Stelle wenden Sie sich an:
This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany's largest scientific organisation.