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Postdoc in Neuroscience – De Paola Lab, Duke-NUS, Singapore

Office of Research - Neuroscience and Behavioural Disorders Programme, Duke-NUS Medical School
Singapore (SG)
Closing date
10 Nov 2023

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Life Science
Job Type
Employment - Hours
Full time
Fixed term

Job Details

The Neuroscience and Behavioural Disorders (NBD) Programme, one of five Signature Research Programmes at Duke-NUS Medical School, is focused on understanding the structure and function of the nervous system, and the neural mechanisms underlying human neurological, psychiatric and eye disorders.
The Translational Neuroscience Group led by Professor Vincenzo De Paola ( at Duke-NUS Medical School is looking for Research Fellows/Senior Research Fellows

The De Paola Lab at Duke-NUS, Singapore aims to understand the regulation of neural network connectivity and function in the neocortex, a brain region affected in numerous developmental and degenerative diseases as well as acute injuries, which are incurable to date. To study complex genetic neuropsychiatric conditions such as Down syndrome, autism and Alzheimer's disease, we are building more advanced human experimental in vivo cellular models. We focus on the role of the synaptic life cycle (i.e. synapse formation and elimination), and on the mechanisms of axon degeneration and regeneration. We combine human iPSC models, structural and functional imaging of in vivo self-assembled human cortical circuitry (as in Real et al Science 2018, complemented with human derived microglia), with state-of-the-art molecular and computational biology skills. 
We are looking for highly motivated, persistent and committed researchers with a strong interest in the wiring and dysfunction of human cortical circuits, and in how we can increase and harness their regenerative potential to transform the treatment of neurodegenerative and neuropsychiatric brain disorders.

We are located in a modern building with state-of-the-arts core facilities adjacent to the Singapore General Hospital and have strong basic, translational and clinical research partnerships throughout Singapore, including the National Neuroscience Institute. Singapore, also known as the Garden City or the Switzerland of Asia, is consistently rated among the places with the highest living standards worldwide (relatively high salaries, low taxes, safe, clean, organised). 

Duke-NUS offers a highly attractive remuneration package, including competitive salary and benefits comparable to the world top institutions, as well as exciting training and career advancement opportunities. 

Key tasks and responsibilities

The selected candidate will perform a variety of research activities under the supervision of the Principal Investigator, including but not limited to the following: - 

  • To take initiative in the planning and executing of research projects.
  • To conceptualise ideas and develop independent research plans, which could attract research funding. 
  • To direct and manage the work of a small research team of junior researchers, graduate and/or undergraduate students.
  • To identify and develop suitable approaches for the collection and analysis of data.
  • To ensure the validity and reliability of data at all times.
  • To maintain accurate and complete records of all findings. 
  • To perform oral presentations and write manuscripts for publications.
  • To develop contacts and research collaborations within the Medical School and the wider community.
  • Perform other related duties incidental to the work described therein.

Job Requirements

  • PhD or MD degree and strong first-author publication record in relevant areas.
  • Experience with human stem cell neurobiology and/or mouse genetics, electrophysiology, viral vectors, stereotaxic surgery is desirable.
  • Demonstrated capability of research independence. 
  • Strategic thinking, management skills and supervision of junior lab members. 
  • Excellent writing, communication and presentation skills.
  • Proven ability to integrate in a team and to establish and maintain effective professional working relationships. 

Applicants should send in a single PDF their CV, list of publications and a statement of research interests clearly linking their track record to the proposed research in our team, as well as arrange to have at least two confidential letters of reference sent by referees to this email address Positions will remain open until filled. 

We regret that only shortlisted candidates will be notified.


The Neuroscience and Behavioural Disorders Programme at Duke-NUS is focused on understanding the structure and function of the nervous systems, and the relation of neural mechanisms in model systems to human neurological, psychiatric and ophthalmological disorders. The research interests of the faculty members range from neural development and circuit regulation to brain imaging, perception and behavior.

Collaborating with the clinical faculty at Singapore General Hospital, the National Neuroscience Institute, the Institute of Mental Health and the Singapore Eye Research Centre, the Programme has a strong footing in neurodegenerative diseases, cognitive disorders, developmental disorders and diseases of the neural retina. The ultimate aim of the work carried out by the principal investigators in the Programme is to unravel the secret behind human intelligence and to translate their discoveries into diagnostic and therapeutic strategies in brain disorders like autism, Parkinson’s disease and dementia.

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