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Postdoctoral Position for Metabolomics Research in Mitochondrial Disorders

Employer
LCSB – Luxembourg Centre for Systems Biomedicine
Location
Luxembourg (LU)
Salary
81 072.84
Closing date
13 Oct 2023

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Discipline
Biomedicine, Chemistry
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

Job Details

The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. 

The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.

Successful candidates will join the Enzymology & Metabolism group, led by Prof. Carole Linster, which deciphers the cellular metabolism in rare and more common neurodegenerative or neurometabolic diseases. We exploit genomic and post-genomic data to fill gaps in metabolic networks, discover new enzyme functions, and elucidate their role in disease. The successful candidate will work in strong collaboration with the Environmental Cheminformatics group, led by Prof. Emma Schymanski, which develops methods to identify unknown chemicals and determine their effects on human health. The open position is part of the EJP RD project GENOMIT, funded by the Luxembourg National Research Fund (FNR), within an international consortium that focuses on establishing an integrated multi-omics pipeline to increase the diagnostic yield for mitochondrial disorders. The project is coordinated by the Technical University of Munich (TUM) and involves partners from 5 other countries. The Luxembourg partner will mainly be involved in the identification of biomarkers for mitochondrial disorders and functional studies on novel variants or genes involved in the pathophysiology of mitochondrial disorders.

Your Role...

  • Perform targeted and untargeted (mostly liquid chromatography) mass spectrometry-based metabolomics analyses in samples of patients with mitochondrial disorders
  • Chemical identification of relevant unknown peaks detected in samples of patients with mitochondrial disorders using cheminformatics approaches and final validation using targeted methods
  • Perform metabolic enzyme assays and metabolomics-based functional studies in human cell and yeast models of mitochondrial disorders
  • Use modern data management and establish precise project documentation
  • Work in a collaborative environment, also with different service-based core platforms (sequencing, metabolomics, and imaging facilities)
  • Active participation in project consortium meetings
  • Independent drafting of project reports and potentially grant proposals
  • Writing manuscripts for publication in high-quality journals
  • Presentation of research findings at international scientific meetings

What we expect from you…

  • PhD degree in analytical chemistry, biochemistry, molecular biology, or another similar life science-related discipline
  • Extensive analytical experience in target and non-target high-resolution mass spectrometry (HRMS/MS), preferably in a metabolomics setting
  • Strong background in metabolic biochemistry and keen interest in mitochondrial biology
  • Strong computational skills, including programming, will be considered as an important asset
  • Solid bioinformatic and biostatistics skills will be required
  • Excellent organizational and management skills
  • Excellent communication skills
  • Fluency in oral and written English is essential

Here’s what awaits you at the LCSB...

  • Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
  • Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
  • Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more

Find out more about us!

In Short...

  • Contract type: Fixed Term Contract 24 Month
  • Work hours: Full Time 40.0 Hours per Week
  • Location: Belval
  • Job reference: UOL05702

The yearly gross salary for every Postdoctoral Researcher at the UL is EUR 81072 (full time)

How to apply...

Applications (in English) should contain the following documents:

  • A detailed Curriculum vitae including a list of publications
  • A cover letter that includes a brief description of previous research experience and the motivation for the specific advertised position
  • Copies of diploma and transcripts
  • Name and contact details of at least three referees

Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.

The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.

About the University of Luxembourg...

University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and has more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide. 

For further information, please contact Assoc. Prof. Carole Linster (email address: carole.linster@uni.lu). Use the job title and reference number mentioned above in the subject line of your email.

Company

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The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. For over a decade, we have developed our expertise in several fields – from genetics to metaproteomics, from enzymology to immunology, from computational biology to cheminformatics – to tackle the growing issue represented by neurodegenerative diseases worldwide. We want to further our understanding of the human brain and improve care for patients in Luxembourg and beyond.

Interdisciplinarity is key

We strongly believe that complex problems can only be solved when the best minds from different disciplines and cultures come together and form a team. The LCSB recruits talented scientists from various disciplines: join the mix of computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries. We excel because we are truly interdisciplinary and together we contribute to science and society.

Are you fascinated by the complexity of the brain? Do you want to decipher its mechanisms to better prevent and treat neurodegeneration? Do you strive for excellence and believe in interdisciplinary collaboration? 3x YES – then join our team!  

Excellent work environment

In the south of Luxembourg, close to neighbouring France, Belgium and Germany, new architecture and the country’s history combine into an innovative campus. Scientists find a state-of-the-art infrastructure that is constantly evolving. At the LCSB, six scientific platforms offer services to all our researchers. Be it imaging, omics, data science or animal models – we have experts and equipment in house.

Here, researchers can concentrate fully on their science: Lab support as well as administrative staff relieve LCSB’s scientists of many tasks. We also value our dynamic corporate company culture, so be prepared for teambuilding events, networking activities and more.

Every day at the LCSB and in Luxembourg is truly international. Our 250 staff have joined us from all around the world, creating a rich and multicultural environment. The LCSB actively encourages researchers to visit international conferences, to join European and global consortia, and of course to invite collaborators to Luxembourg!

Truly connected

The LCSB cooperates closely with hospitals and healthcare professionals. We receive invaluable input from medical doctors and clinical researchers in many fields like neurology, pathology and neurosurgery. Their contribution is essential for the development of interventional therapies or new biomarker-based diagnostic tools and for testing their effectiveness in the clinic. 

We have established strategic partnerships with leading biomedical laboratories worldwide and with all major biological and medical research units in Luxembourg. The LCSB fosters collaboration with industrial partners as well and promotes the translation of fundamental research results into clinical applications.

The connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science. Research at the LCSB is truly connected in many different ways.

LCSB, the place to be for your PhD 

 

We teach interdisciplinarity to the young generations of scientists from day one. Most PhD students are part of Doctoral Training Units: groups of students from diverse fields, all working together on an overarching research topic.

Thanks to a high ratio of academics and post-docs to doctoral candidates, PhD students can benefit from supervision of our internationally recognised experts and additional guidance from colleagues with various levels of experience. Besides high-quality research training, the Doctoral School of Science and Engineering offers complementary training to complete knowledge and skills required for their career development.

The learning doesn’t stop there: pick one of the University’s many free science and soft skill courses, learn a new language or join the free university sports and arts program!

Outstanding Benefits

The university offers a competitive salary package, over six weeks of paid leave and 11 days of public holidays. Family is important to us: staff members can benefit from maternity and parental leave, plus 40 hours of personal time off each year to facilitate private appointments when needed. Luxembourg provides free public schools (including several public international schools) and after-school care as well as subsidised day care for smaller children.

You also benefit from top-notch health insurance. Every university employee is automatically enrolled in the national health scheme (CNS), offering coverage in Luxembourg and in the EU. You will also benefit from travel insurance both for your personal and professional trips. Public transportation is free in Luxembourg!

The university offers some subsidised housing units for doctoral researchers. You also receive meal vouchers and a discount on your meals at university restaurants.

o  More info about the LCSB and its research groups here

o  Find all career opportunities at the LCSB here

About the University of Luxembourg

The University of Luxembourg aspires to become one of Europe’s most highly regarded universities, with a distinctly international and interdisciplinary character.

Its core asset is its well-connected and world-class academic staff. It is known for its research and teaching in targeted areas such as Biomedicine, Data Science and Physics. The university strives to attract creative students and talented young researchers who will help us shape our future.

About biomedical research in Luxembourg

Luxembourg has made research & innovation one of the cornerstones of the nation’s vision for the future. The country has drawn up a national research strategy, built excellent facilities and gained high international recognition in specific domains such as biomedicine and healthcare. The country has the ambition to be a pioneer in implementing cutting-edge health technologies and strives to be among the leading countries in the world in the field of personalised data-driven medicine. Hospitals, public research institutes and the university work hand in hand to speed up the development of more effective preventive and diagnostic tools as well as better and safer treatments for patients. The LCSB, as part of the university, is a driver within this bustling biomedical network.

More information about research in Luxembourg on the Research Luxembourg and EURAXESS websites.

Company info
Website
Location
Esch-sur-Alzette
L-4362
Luxembourg

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