A postdoctoral position is immediately available in the laboratory of Dr. Jun Yang in the Department of Surgery, St. Jude Children’s Research Hospital. The Yang lab investigates epigenetics, splicing, drug development, and novel therapies. He is focusing on the biological functions of histone lysine demethylases (KDMs) in high-risk solid tumors.
The project aims to understand how KDMs coopts oncogenic transcription factors to drive tumorigenesis and metastasis, and use novel KDM inhibitors to target metastasis and disease relapse. To this end, we apply interdisciplinary strategies by integrating genetic approaches (transgenic mouse models and conditional knockout) with cutting-edge systems (Cut&Tag, HiChIP, ATAC-seq, scRNA-seq, spatial transcriptomics), and functional genomics tools (Genome-wide and focused CRISPR libraries, CRISPR knockin, CRIPSRi and CRISPRa) as well as proteomics and metabolomics.
Please see the following articles published over the past 2 years for additional information: Science Translational Medicine. 2022;14(653):eabq2096. Journal of Medicinal Chemistry. 2022;65(14):9564-9579. Cell Reports. 2022;39(12):111000. Science Immunology. 2022;7(70):eabm8161. Nature Communications. 2021;12(1):7204. Science Advances. 2021;7(47):eabj5405. iScience. 2021;24(1):101996.
The successful candidate will have these attributes: (1) PhD in the field of molecular biology, cell biology, biochemistry, or cancer biology. (2) Highly self-motivated, committed, and creative. (3) work effectively both independently and as a member of a team. (4) Excellent written and verbal communication skills.
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