Postdoctoral Research Associate - Surgery

Summary

A postdoctoral position is immediately available in the laboratory of Dr. Jun Yang in the Department of Surgery, St. Jude Children’s Research Hospital. The Yang lab investigates epigenetics, splicing, drug development, and novel therapies. He is focusing on the biological functions of histone lysine demethylases (KDMs) in high-risk solid tumors.

The project aims to understand how KDMs coopts oncogenic transcription factors to drive tumorigenesis and metastasis, and use novel KDM inhibitors to target metastasis and disease relapse. To this end, we apply interdisciplinary strategies by integrating genetic approaches (transgenic mouse models and conditional knockout) with cutting-edge systems (Cut&Tag, HiChIP, ATAC-seq, scRNA-seq, spatial transcriptomics), and functional genomics tools (Genome-wide and focused CRISPR libraries, CRISPR knockin, CRIPSRi and CRISPRa) as well as proteomics and metabolomics.

Please see the following articles published over the past 2 years for additional information: Science Translational Medicine. 2022;14(653):eabq2096.  Journal of Medicinal Chemistry. 2022;65(14):9564-9579.  Cell Reports. 2022;39(12):111000.  Science Immunology. 2022;7(70):eabm8161. Nature Communications. 2021;12(1):7204. Science Advances. 2021;7(47):eabj5405. iScience. 2021;24(1):101996.

Minimum Education

The successful candidate will have these attributes: (1) PhD in the field  of molecular biology, cell biology, biochemistry, or cancer biology.  (2) Highly self-motivated, committed, and creative. (3) work effectively both independently and as a member of a team. (4) Excellent written and verbal communication skills.

Other Information

St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

COVID-19 vaccine:

St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.