Research Associate

Research Associate

Imperial College London

£43,093 - £50,834 per annum

Hammersmith Hospital Campus (East Acton)

Job Summary

You will join Profs Ali and Buluwela’s laboratory in the Division of Cancer. The team focuses on discovering mechanisms of drug resistance and metastasis in breast cancer and translating these into new therapies. Recent successes include the identification of CDK7 as a new therapeutic target for breast cancer, discovery of an oral CDK7 inhibitor and its progression to clinical trials. We employ functional genomic screens, proteomics, RNA-seq and ChIP-seq for identifying mechanisms of resistance and targetable vulnerabilities. These data are validated in pre-clinical findings from 2D/3D models using gene manipulation and selective drugs.

Duties and responsibilities

The post will be focused on investigating mechanisms by which mutations in the estrogen receptor (ER) drive therapy resistance and metastasis in breast cancer patients. The postholder will lead the work to exploit our unique resource of ER-mutant breast cancer models. This will include undertaking transcriptomic/epigenomic profiling to discover new therapeutic approaches for treating patients with treatment-resistant, metastatic breast cancer. In addition, the candidate will provide support/training to research staff, MRes, MD and PhD students within or associated with the group.

Essential requirements

Research Associate: Hold or be about to obtain a PhD, or equivalent level of professional qualifications and experience, in a cancer biology related field

Research Assistant: Near completion of a PhD, or equivalent level of professional qualifications and experience, in a cancer biology related field

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.

Molecular biology experience (ie RNA-Seq, ChIP-seq, proteomics, CRISPR technologies)

Biochemical/cell biology experience

Further Information

This is a full time and fixed term post for 3 years. You will be based at the Hammersmith Campus (East Acton)

Should you require any further details on the role please contact: Prof Simak Ali (simak.ali@imperial.ac.uk)

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 to £41,388 per annum*

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED03854.

Or click on the apply button.