The long-term objective of the Centre for Oncology and Immunology is to employ novel functional screens, animal and cell models including organoids, immuno-oncology approach, as well as advanced genomic and proteomic techniques down to single cell resolution to identify novel “druggable” cancer targets for hard-to-treat malignancies. The ultimate goal is to develop therapeutics against these targets and to conduct clinical trials evaluating these drugs along with biomarkers with an eye to their eventual commercialization worldwide. Success in this venture will address pressing unmet medical needs and establish Hong Kong as a leading hub of innovative anti-cancer and immuno-oncology drug development.
The position will focus on tumor microenvironment in GI and liver cancer under the direction of Prof. Tracy L. McGaha as part of a collaborative program between the University of Hong Kong and the University Health Network/Princess Margaret Cancer Centre (Canada). The successful candidates will work in close collaboration with the principal investigator’s scientific teams at the Centre for Oncology and Immunology and the Princess Margaret Cancer Centre to decipher myeloid/tumor interactions using high dimensional, spatially resolved approaches.
Applicants are expected to contribute to collaborative research projects in discovery of cancer biomarkers using large scale multi-omics approach, organoid technology, and novel animal models, as well as anti-cancer or immuno-oncology drug development.
Qualifications and skills:
Applicants should have strong research background in Biomedical Sciences, Bioengineering or Biological Science, preferably in Cancer Biology, Immunology, Immuno-oncology, Molecular Biology, Genomic, Proteomic, Metabolomic, Bioinformatics Studies, Single Cell Technology or Medicinal Chemistry.
- Possess a demonstrated track record of publishing academic research papers
- Understanding and/or experience in CRISPR/Cas9 technology, high-throughput screening techniques, next generation sequencing, and single cell sequencing technologies
- Experienced in molecular biology laboratory techniques and handling mammalian cell culture
- Specialised research interest in multi-omics profiling, bioinformatics, cancer metabolism, medicinal chemistry, and drug discovery
- Understanding and experience in drug sensitivity screen and identification of new drugs for personalized cancer immuno-therapy
- Experienced in mouse models, xenograft models and biobanking
- Experienced in animal handling technique
- Experienced in clinical trial and establishing translation research infrastructure
Applicants should have a good command of written and spoken English, strong communication skills, and be self-motivated, hardworking and able to work well in an interdisciplinary team.
The appointees shall work in Hong Kong Science and Technology Park.
Overseas graduates are welcome to apply, the qualification awarding institution should be ranked in the top 100 institutions for STEM-related subjects in QS/Shanghai Jiao Tong Uni/Times Higher Education/U.S. News world university rankings.
Applicants for the Postdoctoral Fellow posts should possess a Ph.D. degree or an equivalent qualification in one of the said or related disciplines. (H03/2023/A1/UHN)
A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.
How to apply:
Applicants should submit their up-to-date C.V. and research publication list, quoting the job reference number, with information of current/expected remuneration and availability, to email@example.com.
Review of applications will commence as soon as possible or until the posts are filled, whichever is earlier.
The personal data provided in your application process will be used for recruitment and other employment-related purposes. The personal data may be transferred and disclosed to, and used by, HKU Innovation Holdings Limited and The University of Hong Kong for the above mentioned purposes.
We are an equal opportunities employer and welcome applications from all qualified candidates.