Postdoctoral Research Fellow – IDPs, phase separation, gene regulation

The laboratory of Dr. Shasha Chong in the Division of Chemistry and Chemical Engineering at the California Institute of Technology in Pasadena, CA, is seeking a highly motivated postdoctoral research fellow. The Chong Lab studies the interaction behaviors and functions of intrinsically disordered proteins (IDPs), including their phase separation behaviors. We are interested in understanding how IDPs play roles in transcriptional regulation and other processes in mammalian cells in the context of physiology and disease, including different forms of cancer. We use highly interdisciplinary approaches in our research, including quantitative single-cell and single-molecule imaging, molecular and cell biology, biochemistry, genetics, and proteomics.

The postdoctoral fellow will have the opportunity to participate in diverse projects and collaborate with labs in and outside Caltech. Applicants with interest are welcome to explore the selected works published by the Chong Lab and by Dr. Shasha Chong before coming to Caltech: Chong et al, Cell 2014, Chong et al, Science 2018, Chong et al, Mol Cell 2022, Irgen-Gioro et al, eLife 2022, Chen et al, BioRxiv 2022, Wang et al, Cancer Discov 2023. More information about research in the Chong Lab can be found on the lab website: https://www.schonglab.com.

Qualifications:

The applicant must have received, or be scheduled to receive, a Ph.D. in biochemistry, molecular biology, cell biology, biophysics, chemistry, or other related fields by the start of the appointment. A strong record of research productivity is required. Expertise in molecular cloning is required. Previous experience in one or more of the following techniques/fields is strongly preferred: protein purification, CRISPR-mediated genome-editing, functional genomics, and gene regulation.

How to apply:

Interested applicants should email Dr. Shasha Chong (schong@caltech.edu) a CV and a description of past research experience and future research interests. Following an initial screening of these application materials, appropriate candidates will be contacted by email for letters of reference. Review of applicants will begin immediately and continue until the positions are filled.