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Postdoctoral Research Fellow – IDPs, phase separation, gene regulation

Employer
California Institute of Technology - Chong Lab
Location
Pasadena, California
Salary
$64,480
Closing date
3 Jul 2023

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Discipline
Chemistry
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

Job Details

The laboratory of Dr. Shasha Chong in the Division of Chemistry and Chemical Engineering at the California Institute of Technology in Pasadena, CA, is seeking a highly motivated postdoctoral research fellow. The Chong Lab studies the interaction behaviors and functions of intrinsically disordered proteins (IDPs), including their phase separation behaviors. We are interested in understanding how IDPs play roles in transcriptional regulation and other processes in mammalian cells in the context of physiology and disease, including different forms of cancer. We use highly interdisciplinary approaches in our research, including quantitative single-cell and single-molecule imaging, molecular and cell biology, biochemistry, genetics, and proteomics.

The postdoctoral fellow will have the opportunity to participate in diverse projects and collaborate with labs in and outside Caltech. Applicants with interest are welcome to explore the selected works published by the Chong Lab and by Dr. Shasha Chong before coming to Caltech: Chong et al, Cell 2014, Chong et al, Science 2018, Chong et al, Mol Cell 2022, Irgen-Gioro et al, eLife 2022, Chen et al, BioRxiv 2022, Wang et al, Cancer Discov 2023. More information about research in the Chong Lab can be found on the lab website: https://www.schonglab.com.

Qualifications:

The applicant must have received, or be scheduled to receive, a Ph.D. in biochemistry, molecular biology, cell biology, biophysics, chemistry, or other related fields by the start of the appointment. A strong record of research productivity is required. Expertise in molecular cloning is required. Previous experience in one or more of the following techniques/fields is strongly preferred: protein purification, CRISPR-mediated genome-editing, functional genomics, and gene regulation.

How to apply:

Interested applicants should email Dr. Shasha Chong (schong@caltech.edu) a CV and a description of past research experience and future research interests. Following an initial screening of these application materials, appropriate candidates will be contacted by email for letters of reference. Review of applicants will begin immediately and continue until the positions are filled.

Company

The Chong Lab at Caltech studies the interaction behaviors and functions of intrinsically disordered proteins, including their phase separation behaviors, in the context of physiology and disease. Our research interfaces between biology, chemistry, and physics. Since biomolecular transactions are often highly dynamic, reversible, and heterogeneous, we believe that an in-depth mechanistic understanding of them requires visualizing biomolecules one at a time with high spatiotemporal resolution. To this end, we combine single-molecule imaging, genome editing, biochemical, genetic, and proteomic approaches in our research. Lab website: https://www.schonglab.com/.

 

Company info
Website
Telephone
626-395-5736
Location
1200 East California Boulevard
Pasadena, CA
UNITED STATES OF AMERICA
91125
US

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