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Principal Investigator, Immune System Aging and Inflammation

Calico LLC
South San Francisco, California
Salary is commensurate with professional experience
Closing date
3 Jul 2023

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Life Science
Job Type
Principal Investigator
Employment - Hours
Full time

Who we are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.  Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

We are currently actively recruiting for multiple Principal Investigator positions to lead aging research in the fields of neurobiology, skin biology, immunology, and metabolism. For more details regarding our other Principal Investigator positions, please refer to our careers page.

​​Position description:

Calico seeks Principal Investigators with innovative research programs studying the immune system and inflammation who are excited about applying this knowledge to the field of aging.  Of particular interest is research focused on understanding mechanisms driving immune system dysregulation with age and the physiological impact of these changes.  We are most interested in applicants with demonstrated experience in applying molecular and cell biological approaches to study immunity, with an ability to carry out longitudinal studies that can ascertain causal events in aging. 

The ideal candidate should have a breadth of organismal knowledge to relate immune system aging to changes in tissue homeostasis, metabolism and/or response to infection and cancer.  The candidate should also be interested in identifying ways to therapeutically intervene to promote resilience that are informed by a mechanistic understanding of aging pathobiology. 

Principal Investigators at Calico are expected to lead independent, productive research groups in a fully funded, highly collaborative research environment with support from state-of-the art technology labs, including biochemistry, genomics, mass spectrometry, microscopy, preclinical imaging, mouse physiology, data science and machine learning. Principal Investigators are part of the larger scientific community and are encouraged to publish their work and give seminars.

Position requirements:

  • Ph. D. or M.D. in immunology, biology, physiology, systems biology, or related field
  • Post-doctoral experience or have led an independent research program in either industry or academia
  • Strong record of originality and productivity including impactful publications
  • Must be willing to work onsite at least four (4) days per week

Please include a 2-3 page description of research interests and Resume/CV in the application at

Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.

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