The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, was constituted in December 2020, in partnership with the University Medical Center Göttingen, Germany and the University of Warsaw, Poland. IMol has been established to conduct scientific research and provide training in the fields of biological, chemical, medical, biotechnological, bioinformatics, biophysical, pharmacological, and similar sciences, in the international environment conducive to collaborative efforts, research and development interactions with the biotechnological industry, and wide dissemination of our results. We aim for the development of solutions that will help everyone on this planet live a safer life.
Currently, IMol is seeking highly motivated candidates for positions of Postdocs and PhD students
Please see all the open positions on our career website: https://www.imol.institute/career-lab
Location: Poland, Warsaw 02-247, Flisa 6
Our research groups:
Abdelhalim Azzi, Laboratory of Lipids and Chronobiology
Our lab is interested in understanding the role of phosphoinositides in cell signaling, with a special focus on the phosphoinositide 5-phosphatases. We would like to understand in more detail the exact function of these enzymes in regulation of basic cellular processes such as growth, migration and differentiation. In addition, we are also interested in investigating the role of these enzymes in pathological situations such as cancer.
Maciej Cieśla, Laboratory of Stem Cell RNA Metabolism
Our group is interested in understanding how RNA metabolism is integrated during early steps of stem cell activation. Particularly, we use systems of hematopoiesis and development as a test tube to understand fundamental aspects of splicing regulation. Toward this end, we look at the coordination of a macromolecular machinery of the spliceosome once stem cells decide their fate between self-renewal and differentiation. It is our vision to pave new ways in stem cell biology, while at the same time understanding intricate molecular details that underlie stem cell health and disease.
Nicola De Franceschi, Laboratory of Membrane Machines
We are fascinated by membranes and their unique biophysical properties. We use a bottom-up reconstitution approach to study biological nanomachines that function on membranes, such as membrane pores and membrane-deforming proteins. We also apply this knowledge to build bio-inspired molecular machines that act in concert with membranes to create new functionalities. Furthermore, we aim at understanding the underappreciated role of membranes in the origin of life.
Piotr Gerlach, Laboratory of Structural Virology
We are interested in studying how negative-strand RNA viruses reorganize and exploit cellular translation during infection. We want to identify which host factors are hijacked by viruses for their non-canonical translation strategies and to determine the structures and function of the virus-host protein complexes involved. Our ambition is to open new avenues in the RNA virus field and to set the basis for the broad-spectrum antivirals design.
Remigiusz Serwa, Proteomics Core Facility
We do research in chemical biology. Our main interest lies in the development of new chemoproteomic approaches for the interrogation of interactions between small molecules (e.g. metabolites, co-factors, post-translational modifiers, natural products, approved medicines, drug candidates) and proteins in living cells, whole organisms, or disease model systems.