Chromatin Architecture in Development and Human Health

Keystone Symposia

12 March 2023

Fairmont Empress Victoria / Victoria Conference Centre

Registration Deadline

12 January 2023

The science behind chromatin architecture spans across multiple processes and scales from local DNA polymer folding and chromatin loops, to the organization of the genome into domains and chromosome territories. Such three-dimensional (3D) organization is an important component in the regulation of gene expression, with more recent implications emerging for DNA replication and repair. Furthermore, it has been discovered that genome rearrangements that alter chromatin architecture can lead to devasting developmental defects. This has led to many exciting developments in recent years in the field such as an understanding of the biophysical properties of chromatin organization and function, as well as genetic dissection of topologically associated domains. Therefore, this conference will bring together leaders in the field to discuss fundamental mechanisms driving formation of 3D chromatin structure and its regulation during development as well as how these processes can go awry, leading to human disease. The conference will showcase the interdisciplinary nature of the field, with talks combining state-of-the-art super resolution imaging, sophisticated genetics and single cell regulatory genomics. Additionally, this conference is being held jointly with Epigenetics, Chromatin, Development and Disease, which will encompass themes of chromatin mechanisms, including DNA and RNA modifications, histone modifications, ATP-dependent nucleosome remodeling complexes, histone variants, and chaperones. These two complementary symposia will elucidate the importance of chromatin and epigenetics in cell identity, cellular and transgenerational memory, and will explore functional aspects of nuclear structure and its impact on fundamental biological processes and disease. There will be joint Keynote speakers, as well as joint sessions. By pairing these two conferences together, it is anticipated that there will be a strong interest from researchers and scientists who are working in both fields.