The emerging field of neuroimmunology is one of the most exciting and fast-paced biomedical research areas today. This vastly uncharted territory is yielding new discoveries with profound clinical implications almost daily, which are reshaping the way we see health and disease, from autism, to depression and neurodegenerative diseases. While it is clear that communication between the brain and the immune system plays critical roles in neural development, homeostasis and disease, many of the mechanisms remain elusive. In part this is due to the complexity of nervous system and immune interactions, which involve both innate and adaptive immune cells and pathways, that can have beneficial or detrimental impacts on brain function depending on the context. It is crucial that we understand the mechanisms that give rise to these divergent outcomes, which dictate healthy or disease states, in order to better understand, prevent and treat neurologic diseases. This meeting will bring together an interdisciplinary group of scientists across the spectrum of basic neuroscience to classical immunology and everything in between to discuss emerging topics at the intersection of these fields. The program features an extraordinary depth and breadth of science spanning and integrating these disciplines, including: (1) Peripheral immunity, inflammation, and interactions between the brain and the periphery; (2) Microglia function and dysfunction; (3) Microbiome and Gut-Brain Axis; (4) Immune mechanisms of synapse loss in development and disease; (5) Mechanisms of neuroimmune communication at brain borders; (5) Glymphatic-lymphatic connections; and (6) Immune mechanisms of aging and resilience. The program will also include several workshops on new discoveries, tools and approaches to analyze and integrate big-data (omics) aspects of neuroimmunology research, and to model neural-immune signaling in different contexts, including human disease. Ultimately, this meeting aims to foster and cultivate cross-disciplinary discussions and collaborations, as well as provide opportunities for outstanding senior leaders to inspire young scientists in the field.